Bone microarchitecture and bone strength relationships to muscle quantity, quality and function in older adults
老年人骨微结构和骨强度与肌肉数量、质量和功能的关系
基本信息
- 批准号:9901926
- 负责人:
- 金额:$ 41.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-18 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAncillary StudyBiologyBiopsyBone DensityCharacteristicsClinicalComplexCreatineDataElderlyEnrollmentFailureFatty acid glycerol estersFinite Element AnalysisFractureFundingFunding OpportunitiesGoalsHip region structureIndividualInterventionInvestigationLeadLinkMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMechanicsMethodsMissionMorphologyMovementMuscleMuscle ContractionMusculoskeletal DiseasesMusculoskeletal SystemNational Institute of Arthritis and Musculoskeletal and Skin DiseasesObservational StudyOlder PopulationOutcomeParticipantPeripheralPhysical activityPreventionProcessPropertyProspective StudiesRadialResearch SupportResolutionResourcesScienceSex DifferencesSignal TransductionSiteSkeletal MuscleTestingThickTimeTissuesWeight-Bearing stateWomanX-Ray Computed Tomographyage groupage relatedbonebone strengthcost efficientdensitydisabilityimprovedin vivomenmuscle agingmuscle formmuscle strengthnovelolder menolder womenosteoporosis with pathological fracturequadriceps muscleradius bone structurerecruitsexskeletaltheoriestibia
项目摘要
The long-term goal of the project is to substantially improve our understanding of the interaction between bone
and muscle. The “mechanostat theory” proposes that bone adapts its morphology and strength to long-term
loads exerted by muscle contraction (1). However, the bidirectional signaling between muscle and bone that
has emerged broadens the relationship beyond that of a purely mechanical perspective (2). We propose to
examine the association between maximal capacity of muscle to generate ATP (ATP-max) by 31P-Magnetic
Resonance Spectroscopy (31P –MRS), quadriceps contractile volume by MRI, total muscle mass (TMM) by D3
creatine dilution (D3Cr), and functional muscle power and bone microarchitecture and strength. The
underlying scientific premise is that age related declines in the capacity to generate ATP in muscle, muscle
volume, TMM and functional power lead to decreases in bone strength and poor bone microarchitecture. This
proposal builds on the Study of Muscle, Mobility and Aging (SOMMA), the first prospective study of muscle
aging aimed to study the contributions of skeletal muscle biology and function to major mobility disability. We
propose to extend SOMMA to include important skeletal measures of bone strength using high-resolution
peripheral quantitative computed tomography (HRpQCT). To our knowledge, no studies have linked ATP-max
and quadriceps contractile volume to volumetric BMD, microarchitecture and strength (failure load as assessed
by finite element analysis). We will examine these characteristics globally and separately in the trabecular and
cortical compartments and in a weight bearing (tibia) and non-weight bearing (radius) bone site. The D3Cr
method of measuring TMM is limited to men enrolled in the Osteoporotic Fractures in Men study (MrOS; mean
age 84 yrs). In SOMMA we will be able to study the D3Cr TMM associations with the HRpQCT parameters on
a wider age group of both men and women. Establishing HRpQCT relationships to TMM and functional power
from the stair climb may identify target outcomes for interventions that can improve both tissues (2). We will
recruit 400 of the 438 SOMMA subjects in Pittsburgh. Our proposal offers a cost-efficient opportunity to
investigate the bone-muscle interaction in older adults using state-of-the-art measurements. We propose the
following specific aims: Aim 1: To determine the association of bone microarchitecture, volumetric BMD, and
bone strength (failure load) globally and in the trabecular and cortical compartments separately to in-vivo ATP-
max, contractile muscle volume and total skeletal muscle mass. Aim 2: To determine the association
between functional muscle power as measured by the stair climb to HRpQCT parameters of volumetric
density, microarchitecture and strength. Aim 3, Exploratory: To explore sex differences in the associations
studied in Aims 1 and 2. OVERALL IMPACT: This SOMMA ancillary study will be the first to study novel
properties of muscle biology, volume, and functional power and their relationships to bone strength in a well-
characterized population of older men and women.
该项目的长期目标是大大提高我们对骨骼之间相互作用的理解
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JANE Ann CAULEY其他文献
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{{ truncateString('JANE Ann CAULEY', 18)}}的其他基金
Sleep, Falls and Fractures in men and women: Role of nocturnal hypoxia
男性和女性的睡眠、跌倒和骨折:夜间缺氧的作用
- 批准号:
10487391 - 财政年份:2021
- 资助金额:
$ 41.27万 - 项目类别:
Sleep, Falls and Fractures in men and women: Role of nocturnal hypoxia
男性和女性的睡眠、跌倒和骨折:夜间缺氧的作用
- 批准号:
10179623 - 财政年份:2021
- 资助金额:
$ 41.27万 - 项目类别:
Bone microarchitecture and bone strength relationships to muscle quantity, quality and function in older adults
老年人骨微结构和骨强度与肌肉数量、质量和功能的关系
- 批准号:
10237325 - 财政年份:2019
- 资助金额:
$ 41.27万 - 项目类别:
Bone microarchitecture and bone strength relationships to muscle quantity, quality and function in older adults
老年人骨微结构和骨强度与肌肉数量、质量和功能的关系
- 批准号:
10616465 - 财政年份:2019
- 资助金额:
$ 41.27万 - 项目类别:
Bone microarchitecture and bone strength relationships to muscle quantity, quality and function in older adults
老年人骨微结构和骨强度与肌肉数量、质量和功能的关系
- 批准号:
10019331 - 财政年份:2019
- 资助金额:
$ 41.27万 - 项目类别:
NATIONAL CHILDREN'S STUDY--PITTSBURGH-WESTMORELAND COUNTY STUDY CENTER
全国儿童学习中心--匹兹堡-威斯特摩兰县学习中心
- 批准号:
8557289 - 财政年份:2012
- 资助金额:
$ 41.27万 - 项目类别:
3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical Center
3 of 4:骨质疏松性骨折 (SOF) 研究-匹兹堡临床中心
- 批准号:
7927143 - 财政年份:2009
- 资助金额:
$ 41.27万 - 项目类别:
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