Race/Ethnicity, Psychosocial and Environmental Stressors, and Telomere Length

种族/民族、心理和环境压力因素以及端粒长度

• 批准号: 7874465
• 负责人: Arline T Geronimus
• 金额: $ 37.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874465
• 关键词: Adult; Affect; Age; Aging; Area; Arts; Biochemistry; Biochemistry and Cellular Biology; Biological; Biological Aging; Biological Process; Blood; Cardiovascular system; Cell Aging; Cellular biology; Characteristics; Chronic; Chronic Disease; Cohort Effect; Collaborations; Collection; Communities; Community Health; Data; Data Set; Deterioration; Development; Differential Mortality; Disadvantaged; Disease; Disease Outcome; Economics; Ensure; Environment; Estradiol; Ethnic Origin; Ethnic group; Ethnography; Exposure to; F2-Isoprostanes; Face; Follow-Up Studies; Gender; Health; Health Services; Health Surveys; Healthcare; Historical Survey; Hormones; Inequality; Inflammation; Knowledge; Learning; Length; Leukocytes; Life; Life Expectancy; Light; Link; Measurement; Measures; Mediating; Mediator of activation protein; Metabolic; Methods; Michigan; Modeling; Molecular; Molecular Biology; Morbidity - disease rate; Neighborhoods; Nerve; Onset of illness; Oxidative Stress; Pathway interactions; Pattern; Physiology; Population; Population Study; Process; Psychology; Public Health; Race; Research; Research Personnel; Risk; Sampling; Schedule; Scientist; Series; Social Sciences; Socioeconomic Status; Staging; Stress; Surveys; Telomerase; Telomere Shortening; Testing; Universities; Venous; Vitamin E; Weather; Woman; Work; age effect; aging population; allostatic load; base; behavioral/social science; biological adaptation to stress; body system; coping; cost; environmental stressor; experience; health disparity; health inequalities; hypothalamic pituitary axis; illness length; improved; insight; interdisciplinary collaboration; interest; middle age; mortality; psychosocial; public health relevance; racial and ethnic; racial difference; response; social; socioeconomics; sound; stressor; telomere; theories; urban poverty area; young adult

DESCRIPTION (provided by applicant): We propose to conduct the first community-based study of racial differences in telomere length and allostatic load in adults of broad age range and their association with urban stressors. We hypothesize that chronic stressors experienced by black urban residents accelerate biological aging and chronic disease onset. Evidence suggests that leukocyte telomere length (TL) may be an indicator of biological age that can be affected by stress; and that allostatic load is an indicator of stress-mediated wear on important body systems. We have a unique opportunity to supplement survey data scheduled to be collected by the Healthy Environments Partnership (HEP) a partnership between the University of Michigan and community-based organizations and health service agencies in Detroit with blood collection and lab analyses of telomere length, telomere-related compounds, and allostatic load, including measures of the biological stress response, inflammation, and cardiovascular and metabolic risk. By appending a venous blood draw to the HEP survey, we can construct a data set including these biomeasures and detailed psychosocial and physical environmental measures in a cost-effective way; enhance access to a hard-to-reach population; and facilitate dissemination of study results to improve community health. We will estimate a series of regressions of TL and allostatic load on race, controlling for the confounding effects of age, gender, and socioeconomic characteristics and exploring the extent to which psychosocial or environmental stressors mediate remaining racial differences. To ensure findings are not driven by functional form we will reanalyze the data using matching methods. We will also model disease outcomes, conditional on telomere length, on high oxidative stress or low telomerase activity to explore biological mechanistic pathways between telomere length and chronic disease. Our investigative team brings exceptional expertise in social and behavioral science, cell biology, psychology and biochemistry to insure state-of-the art telomere measurement, theory-driven and statistically sound social science measures and models, and appropriate interpretation of study findings to provide important insights. We expect study findings to shed light on the plausibility of cumulative stress hypotheses to explain the social patterning of disease; the viability of telomere length as a biomeasure of aging; and the mechanistic pathways through which stressors may be linked to telomere length and disease processes. If findings from this interdisciplinary collaborative effort support study hypotheses, this could constitute a significant advance in the understanding of the biological mechanisms that underlie racial inequality in health. PUBLIC HEALTH RELEVANCE: Learning how social factors work through biological mechanisms to impact health is fundamental to understanding racial health disparities. By studying personal and neighborhood stressors and the health of Detroit residents in an interdisciplinary collaboration, we hope to shed light on this question.

描述（由申请人提供）：我们建议进行第一个以社区为基础的研究，研究广泛年龄范围的成年人端粒长度和非稳态负荷的种族差异及其与城市压力源的关系。我们假设，黑人城市居民经历的慢性压力加速生物衰老和慢性疾病的发病。有证据表明，白细胞端粒长度（TL）可能是一个指标的生物学年龄，可以受到压力的影响;和非稳态负荷是一个指标的压力介导的磨损对重要的身体系统。我们有一个独特的机会来补充计划由健康环境合作伙伴关系（HEP）收集的调查数据，该合作伙伴关系是密歇根大学与底特律社区组织和卫生服务机构之间的合作关系，包括血液收集和端粒长度的实验室分析，端粒相关化合物和非稳态负荷，包括生物应激反应，炎症，心血管和代谢风险的测量。通过在HEP调查中附加静脉抽血，我们可以以具有成本效益的方式构建一个数据集，其中包括这些生物测量以及详细的心理社会和物理环境测量;增加对难以接触的人群的访问;并促进研究结果的传播，以改善社区健康。我们将估计一系列的回归TL和allostatic负荷的种族，控制年龄，性别和社会经济特征的混杂效应，并探讨在何种程度上心理社会或环境压力调解剩余的种族差异。为了确保发现不是由功能形式驱动的，我们将使用匹配方法重新分析数据。我们还将模拟疾病的结果，条件是端粒长度，高氧化应激或低端粒酶活性，以探索端粒长度和慢性疾病之间的生物机制途径。我们的调查团队在社会和行为科学，细胞生物学，心理学和生物化学方面拥有卓越的专业知识，以确保最先进的端粒测量，理论驱动和统计上合理的社会科学措施和模型，以及对研究结果的适当解释，以提供重要的见解。我们希望研究结果能够阐明累积压力假说的可行性，以解释疾病的社会模式;端粒长度作为衰老生物测量的可行性;以及压力源可能与端粒长度和疾病过程相关的机制途径。如果这项跨学科合作的结果支持研究假设，这可能是对健康方面种族不平等的生物学机制的理解的重大进步。公共卫生相关性：了解社会因素如何通过生物机制影响健康是理解种族健康差异的基础。通过跨学科合作研究个人和社区压力源以及底特律居民的健康状况，我们希望能够阐明这个问题。