Bone Marrow Stem Cells and the Microenvironment of Chronic Wounds

骨髓干细胞与慢性伤口的微环境

• 批准号: 7797471
• 负责人: Evangelos Van Badiavas
• 金额: $ 30.43万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797471
• 关键词: Address; Affect; Age; American; Animal Model; Animals; Aspirate substance; Autologous; Beds; Biomedical Engineering; Blood Vessels; Bone Marrow; Bone Marrow Cells; Bone Marrow Stem Cell; Caring; Cells; Chronic; Clinical; Clinical Protocols; Clinical Research; Cultured Cells; Decubitus ulcer; Defect; Disease; Effectiveness; Elderly; Engraftment; Environment; Ethics; Failure; Growth Factor; Hair follicle structure; Healed; Healthcare; Healthcare Systems; Histologic; Human; Immune; Ischemia; Label; Laboratories; Lead; Leg Ulcer; Malnutrition; Modality; Morbidity - disease rate; Mus; Natural regeneration; Organ; Outcome; Oxidative Stress; Pain; Patients; Phenotype; Protocols documentation; Quality of life; Recruitment Activity; Research Personnel; Safety; Sebaceous Glands; Skin; Skin Tissue; Source; Stem cells; Structure; System; Tissues; Treatment outcome; Venous; Work; Wound Healing; Xenograft Model; Xenograft procedure; arm; cost; diabetic; frailty; healing; human subject; improved; mortality; mouse model; progenitor; programs; research study; response; senescence; stem; stem cell biology; stem cell niche; trafficking; wound

DESCRIPTION (provided by applicant): Chronic wounds represent a significant morbidity to the elderly and are a substantial financial burden to health care for the elderly. Several advances have been made however many patients still present with unresponsive lower extremity ulcers. The emerging field of stem cell biology may open new avenues for treatment for chronic wounds as well as a variety of other disorders. There is growing evidence that stem cells from one organ can make tissues of another organ. Our preliminary experiments indicate that some bone marrow cells can incorporate and regenerate wounded skin tissues. In a clinical protocol we have been able to heal recalcitrant wound with the application of bone marrow aspirate and cultured bone marrow stem cells. This application will address improving on our preliminary findings and identifying those bone marrow cells that are important in contributing to wound healing.

描述（由申请人提供）：慢性伤口是老年人的一种严重发病率，是老年人医疗保健的一个重大经济负担。虽然已经取得了一些进展，但许多患者仍然存在下肢溃疡无反应。新兴的干细胞生物学领域可能为治疗慢性伤口以及各种其他疾病开辟新的途径。越来越多的证据表明，来自一个器官的干细胞可以制造另一个器官的组织。我们的初步实验表明，一些骨髓细胞可以合并和再生受伤的皮肤组织。在临床方案中，我们已经能够通过应用骨髓穿刺液和培养的骨髓干细胞来治愈顽固性伤口。这项申请将解决改善我们的初步研究结果，并确定那些骨髓细胞是重要的，有助于伤口愈合。