Bone Marrow Stem Cells and the Microenvironment of Chronic Wounds

骨髓干细胞与慢性伤口的微环境

• 批准号: 8061956
• 负责人: Evangelos Van Badiavas
• 金额: $ 29.25万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061956
• 关键词: Address; Affect; Aging; American; Animal Model; Animals; Aspirate substance; Autologous; Beds; Biomedical Engineering; Blood Vessels; Bone Marrow; Bone Marrow Cells; Bone Marrow Stem Cell; Caring; Cells; Chronic; Clinical; Clinical Protocols; Clinical Research; Cultured Cells; Decubitus ulcer; Defect; Diabetic ulcer; Disease; Effectiveness; Elderly; Engraftment; Environment; Ethics; Failure; Growth Factor; Hair follicle structure; Healed; Healthcare; Healthcare Systems; Histologic; Human; Immune; Ischemia; Label; Laboratories; Lead; Leg Ulcer; Malnutrition; Modality; Morbidity - disease rate; Mus; Natural regeneration; Organ; Outcome; Oxidative Stress; Pain; Patients; Phenotype; Protocols documentation; Quality of life; Recruitment Activity; Research Personnel; Safety; Sebaceous Glands; Skin; Skin Tissue; Source; Stem cells; Structure; System; Tissues; Treatment outcome; Varicose Ulcer; Work; Wound Healing; Xenograft Model; Xenograft procedure; arm; cost; frailty; healing; human subject; improved; mortality; mouse model; progenitor; programs; research study; response; senescence; stem; stem cell biology; stem cell niche; trafficking; wound

DESCRIPTION (provided by applicant): Chronic wounds represent a significant morbidity to the elderly and are a substantial financial burden to health care for the elderly. Several advances have been made however many patients still present with unresponsive lower extremity ulcers. The emerging field of stem cell biology may open new avenues for treatment for chronic wounds as well as a variety of other disorders. There is growing evidence that stem cells from one organ can make tissues of another organ. Our preliminary experiments indicate that some bone marrow cells can incorporate and regenerate wounded skin tissues. In a clinical protocol we have been able to heal recalcitrant wound with the application of bone marrow aspirate and cultured bone marrow stem cells. This application will address improving on our preliminary findings and identifying those bone marrow cells that are important in contributing to wound healing.

描述(申请人提供)：慢性伤口对老年人来说是一种严重的发病率，对老年人的医疗保健来说是一个巨大的经济负担。虽然取得了一些进展，但仍有许多患者出现了无反应的下肢溃疡。干细胞生物学的新兴领域可能会为治疗慢性伤口和其他各种疾病开辟新的途径。越来越多的证据表明，来自一个器官的干细胞可以形成另一个器官的组织。我们的初步实验表明，一些骨髓细胞可以整合和再生受伤的皮肤组织。在一项临床方案中，我们已经能够通过应用骨髓抽吸物和培养的骨髓干细胞来治愈顽固性伤口。这项应用将致力于改进我们的初步发现，并确定那些对伤口愈合起重要作用的骨髓细胞。

项目成果

Potential benefits of allogeneic bone marrow mesenchymal stem cells for wound healing.

• DOI: 10.1517/14712598.2011.606212
• 发表时间: 2011-11
• 期刊: Expert opinion on biological therapy
• 影响因子: 4.6
• 作者: Badiavas AR;Badiavas EV
• 通讯作者: Badiavas EV

Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing.

• DOI: 10.1186/s13287-015-0001-9
• 发表时间: 2015-03-13
• 期刊: Stem cell research & therapy
• 影响因子: 7.5
• 作者: Rodriguez-Menocal L;Shareef S;Salgado M;Shabbir A;Van Badiavas E
• 通讯作者: Van Badiavas E