Viability, specificity and yields of clinical grade primary and expanded human fetal cells for neural transplantation

用于神经移植的临床级原代和扩增人类胎儿细胞的活力、特异性和产量

基本信息

  • 批准号:
    G0800394/1
  • 负责人:
  • 金额:
    $ 87.49万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2008
  • 资助国家:
    英国
  • 起止时间:
    2008 至 无数据
  • 项目状态:
    已结题

项目摘要

The MRC has sponsored a multicentre clinical trial on the safety and fesibility of fetal neural tissue transplantation in a severe progressive degenerative disease of the brain, Huntington s disease. However, this trial has been suspended after completion of the first 5 transplants because of the implementation of new EU regulations that require pharmaceutical grade handling of any cells or tissues used in patients. Although the UK trial had fully assessed the safety of the cells, we could not comply with the very stringent environmental control conditions required for accreditation. We have therefore undertaken a full rebuild of the laboratories to comply with the new regulations. In the present grant, we will undertake the detailed studies required to validate new laboratory procedures for cell preparation and expansion in cell culture and confirm the efficacy of the cells in animal models. This will allow us to complete the suspended HD trial, and to extend the multicentre UK cell transplant programme to trials in Parkinson s as well as Huntington s disease.
MRC赞助了一项关于胎儿神经组织移植治疗严重进行性脑退行性疾病亨廷顿病的安全性和可行性的多中心临床试验。然而,这项试验在完成前5次移植后暂停,因为欧盟实施了新的法规,要求对患者使用的任何细胞或组织进行药物级处理。虽然英国的试验已全面评估电池的安全性,但我们未能符合认证所需的非常严格的环境控制条件。因此,我们对实验室进行了全面重建,以符合新规定。在目前的拨款中,我们将进行所需的详细研究,以验证细胞培养中细胞制备和扩增的新实验室程序,并确认细胞在动物模型中的功效。这将使我们能够完成暂停的HD试验,并将英国多中心细胞移植计划扩展到帕金森病和亨廷顿病的试验。

项目成果

期刊论文数量(0)
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Stephen Dunnett其他文献

Animal models of Parkinson’s disease and L-dopa induced dyskinesia: How close are we to the clinic?
  • DOI:
    10.1007/s00213-007-0931-8
  • 发表时间:
    2007-09-25
  • 期刊:
  • 影响因子:
    3.300
  • 作者:
    Emma Lane;Stephen Dunnett
  • 通讯作者:
    Stephen Dunnett
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease
特兰斯欧洲开放性标签试验:人类胎儿腹侧中脑移植治疗中度帕金森病患者
  • DOI:
    10.1038/s41587-025-02567-2
  • 发表时间:
    2025-05-02
  • 期刊:
  • 影响因子:
    41.700
  • 作者:
    Roger A. Barker;Nicholas P. Lao-Kaim;Natalie Valle Guzman;Dilan Athauda;Hjalmar Bjartmarz;Anders Björklund;Alistair Church;Emma Cutting;Danielle Daft;Viswas Dayal;Stephen Dunnett;Amy Evans;Shane Grealish;Naomi Hannaway;Xiaoling He;Sam Hewitt;Zinovia Kefalopoulou;Philipp Mahlknecht;Antonio Martín-Bastida;Krista Farrell;Sarah Moore;Harry Bulstrode;Tagore Nakornchai;Jenny Nelander-Wahlestedt;Linnea Roupé;Gesine Paul;Kathryn Peall;Anne Rosser;Adriana Roca-Fernández;Sophie Rowlands;Anne-Marie McGorrian;Caroline Scherf;Ngoc Nga Vinh;Victoria Roberton;Claire Kelly;Mariah Lelos;Eduardo Torres;Kate Shires;Rachel Hills;Debbie Williams;Andreas-Antonios Roussakis;Krista Sibley;Pamela Tyers;Ruwani Wijeyekoon;Caroline Williams-Gray;Thomas Foltynie;Paola Piccini;Robert Morris;Stanley E. Lazic;Olle Lindvall;Malin Parmar;Hakan Widner
  • 通讯作者:
    Hakan Widner

Stephen Dunnett的其他文献

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{{ truncateString('Stephen Dunnett', 18)}}的其他基金

Basic science and preclinical development of cell transplantation for basal ganglia disorders
细胞移植治疗基底神经节疾病的基础科学和临床前进展
  • 批准号:
    G1001257-E01/1
  • 财政年份:
    2011
  • 资助金额:
    $ 87.49万
  • 项目类别:
    Research Grant
Development and validation of functional cell therapies for Huntington's and Parkinson's diseases
亨廷顿病和帕金森病功能性细胞疗法的开发和验证
  • 批准号:
    G0500794/1
  • 财政年份:
    2006
  • 资助金额:
    $ 87.49万
  • 项目类别:
    Research Grant

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