Transcriptional control of antigenic variation in the malaria parasite Plasmodium falciparum

疟原虫恶性疟原虫抗原变异的转录控制

• 批准号: DP0879293
• 负责人: Dr Michael Duffy
• 金额: $ 20.45万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879293
• 关键词: Transcriptional; control; antigenic; variation; malaria

Malaria is a major health concern for the Australian Defence Personnel recently deployed in East Timor, Afghanistan and the Solomon Islands and is endemic in our immediate neighbours Indonesia and Papua New Guinea. Australia is susceptible to malaria and climate change could extend the mosquitos range to large population centres of Northern Australia causing malaria in Australia. This study would clarify how malaria parasites evade the host's immune response and help to protect Australia by providing drug targets for the control of this invasive disease.

疟疾是最近部署在东帝汶、阿富汗和所罗门群岛的澳大利亚国防人员的一个主要健康问题，在我们的近邻印度尼西亚和巴布亚新几内亚也是地方病。澳大利亚易受疟疾影响，气候变化可能会将蚊子的范围扩大到澳大利亚北方的大型人口中心，从而在澳大利亚引发疟疾。这项研究将阐明疟疾寄生虫如何逃避宿主的免疫反应，并通过提供控制这种入侵性疾病的药物靶点来帮助保护澳大利亚。