The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets

新型必需溴结构域蛋白在协调疟疾寄生虫基因调控中的作用及其作为抗疟疾靶点的潜力

• 批准号: nhmrc : 1128975
• 负责人: Dr Michael Duffy
• 金额: $ 47.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-novel-essential-malarial-targets/948322
• 关键词: role; novel; essential; bromodomain; proteins

Malaria kills over 400,000 people a year and new therapies are needed. Malaria parasites activate groups of genes by novel mechanisms that could be targeted by drugs. We will characterise a novel group of proteins to identify those that activate genes essential for parasite survival. We will also search for molecules that inhibit the proteins and kill malaria parasites. Thus we will discover how parasites control their genes and identify drug targets and inhibitors for drug development.

疟疾每年造成40多万人死亡，需要新的疗法。疟疾寄生虫通过新的机制激活基因组，这些机制可以被药物靶向。我们将研究一组新的蛋白质，以确定那些激活寄生虫生存所必需的基因。我们还将寻找抑制蛋白质和杀死疟疾寄生虫的分子。因此，我们将发现寄生虫如何控制它们的基因，并为药物开发确定药物靶标和抑制剂。