Pacific Southwest RCE for Biodefense & Emerging Infectious Diseases Research

描述（由申请人提供）：太平洋西南地区生物防御和新发疾病卓越中心（“中心”）是一个研究联盟，包括7个项目中的34个项目。该中心还设有五个差异化的核心设施，为整个地区服务。第九区的所有四个州（AZ，CA，HI和NV）都代表了该中心的27个教育，研究，商业和政府机构。该中心的总体目标是杰出的科学，通过多学科和协作方法以及平衡基础和转化研究的组合来实现。该中心的主要主题是美国西部，太平洋沿岸和拉丁美洲的生物防御相关性或新兴疾病的感染。这七个方案是：（1）登革热，（2）病毒性人畜共患病，包括沙粒病毒和尼帕病毒，（3）肉毒杆菌神经毒素，（4）B类伯克霍尔德氏菌属，（5）兔热病，（6）球孢子菌病，和（7）用于预防人类感染的靶向疫苗。该研究的应用包括改进的诊断，新型治疗剂和疫苗平台。该中心的其他主要职能是：（a）与公共卫生机构合作，利用其集体专业知识、资源和设施应对传染病紧急情况;（B）培养有才华的年轻研究人员和新近进入该研究领域的更成熟的研究人员的职业生涯;以及（c）为调查人员和工作人员提供一个区域范围的培训设施，以学习在生物封隔条件下的安全操作。 战略管理层/行政核心： 项目概要：行政核心的主要职能如下：（1）全面协调中心内的活动，特别是各个项目和核心设施之间的活动;（2）监督项目、核心项目、职业发展项目和发展项目的进展;（4）领导中心对生物恐怖事件或其他相关传染病紧急情况的反应;（5）RCE范围内的沟通和合作;（5）监督材料、数据和设施的生物安全和安保，以及遵守特定代理人条例的情况;（6）促进核心设施的最佳利用;（5）财务管理、记录保存和提交报告;以及（7）代表RCE参加会议，并与美国国立卫生研究院、其他政府机构和行业进行互动。

DESCRIPTION (provided by applicant): Pacific-Southwest Regional Center of Excellence for Biodefense and Emerging Diseases ("the Center") is a research consortium comprising 34 projects clustered within seven programs. The Center also features five differentiated core facilities that serve the entire region. All four states (AZ, CA, HI, and NV) of Region IX are represented among the 27 educational, research, commercial, and governmental institutions of the Center. The overall goal of the Center is outstanding science, achieved with a multidisciplinary and collaborative approach and a portfolio that balances basic and translational research. The Center's major theme is infections of the western United States, the Pacific Rim, and Latin America of relevance for biodefense or as emerging diseases. The seven programs are: (1) dengue, (2) viral zoonoses, including arenaviruses and Nipah virus, (3) botulinum neurotoxin, (4) Category B Burkholderia species, (5) tularemia, (6) coccidioidomycosis, and (7) reservoir-targeted vaccines for prevention of human infections. Applications of the research include improved diagnostics, novel therapeutic agents, and vaccine platforms. Other key functions of the Center are: (a) responding, in cooperation with public health agencies, to infectious diseases emergencies with its collective expertise, resources, and facilities; (b) fostering the careers of talented young investigators and more established investigators newly-entering this research field; and (c) providing a region-wide training facility for investigators and staff to learn safe operations under biocontainment conditions. STRATEGIC MANAGEMENT PLAN/ADMINISTRATIVE CORE: PROJECT SUMMARY: Major functions of the administrative core are the following: (1) overall coordination of activities within the Center, particularly between individual programs and core facilities; (2) monitoring of progress of programs, cores, career development projects, and developmental projects; (4) leadership of the RCE's response to a bioterrorism incident or other relevant infectious diseases emergencies; (5) RCE-wide communications and collaborations; (5) oversight of biosafety and security of materials, data, and facilities and of compliance with select agent regulations; (6) facilitating optimum usage of core facilities; (5) financial management, record keeping, and filing reports; and (7) representation of the RCE at meetings and in interactions with the National Institutes of Health, other government agencies, and industry.