Total Synthesis of the Litophynins, Ether-Bridged Cembranoid Natural Products of Marine Origin

海洋来源的醚桥西松烷天然产物 Litophynin 的全合成

• 批准号: GR/T21905/02
• 负责人: J Stephen Clark
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=GR%2FT21905%2F02
• 关键词: Total; Synthesis; Litophynins; Ether; Bridged

The proposed research programme concerns the total synthesis of members of the litophynin family of marine natural products. The litophynins are a sub-class of the cladiellin family of bridged cembranoids that possess significant biological activities and have not been synthesised previously. The research programme will focus on the discovery of novel routes to the litophynins that will be sufficiently efficient and general to be adapted to the construction of many of the numerous structurally related bioactive marine natural products.The intended synthetic approach to the rapid construction of the highly functionalised bridged-ether core of the litophynins will incorporate metal carbenoid and rearrangement methodology pioneered by the Clark Group. A variety of efficient annulation strategies will then be employed to build the tricyclic structure of the litophynins, and subsequent elaboration will be used to prepare individual members of the family.

拟议的研究方案涉及海洋天然产品中的木犀草素家族成员的全部合成。Litophynins是桥联西膜类化合物中Cladiellin家族的一个亚类，具有重要的生物活性，以前没有合成过。研究计划将集中于发现合成木犀草素的新路线，这些路线将足够有效和通用，以适应许多与结构相关的生物活性海洋天然产物的构建。旨在快速构建木犀草素的高度功能化桥醚核心的预期合成方法将结合克拉克集团开创的金属类卡宾和重排方法。然后，将采用各种有效的环化策略来构建列叶绿素的三环结构，随后的精制将用于准备家庭的个别成员。

项目成果

Total syntheses of multiple cladiellin natural products by use of a completely general strategy.

• DOI: 10.1021/jo302542h
• 发表时间: 2013-01
• 期刊: The Journal of organic chemistry
• 作者: J. Clark;Raphaëlle Berger;Stewart T. Hayes;H. Senn;L. Farrugia;L. Thomas;Angus J. Morrison;L. Gobbi