Total Synthesis of the Litophynins, Ether-Bridged Cembranoid Natural Products of Marine Origin

拟议的研究方案涉及海洋天然产品的石蒜黄素家族成员的全合成。litophynins是桥连西松烷类化合物的cladiellin家族的一个亚类，具有显著的生物活性，并且以前没有合成过。该研究计划将侧重于发现新的路线litophynins，将是足够有效的和一般的，以适应许多结构相关的生物活性的海洋天然产品的建设。拟合成方法的快速建设的高度功能化的桥醚核心的litophynins将纳入金属卡宾和重排方法的克拉克集团开创。然后将采用各种有效的成环策略来构建litophynins的三环结构，随后的详细说明将用于制备该家族的各个成员。

The proposed research programme concerns the total synthesis of members of the litophynin family of marine natural products. The litophynins are a sub-class of the cladiellin family of bridged cembranoids that possess significant biological activities and have not been synthesised previously. The research programme will focus on the discovery of novel routes to the litophynins that will be sufficiently efficient and general to be adapted to the construction of many of the numerous structurally related bioactive marine natural products.The intended synthetic approach to the rapid construction of the highly functionalised bridged-ether core of the litophynins will incorporate metal carbenoid and rearrangement methodology pioneered by the Clark Group. A variety of efficient annulation strategies will then be employed to build the tricyclic structure of the litophynins, and subsequent elaboration will be used to prepare individual members of the family.