Encapsulated chemical and biological catalysts

封装的化学和生物催化剂

• 批准号: GR/T28942/02
• 负责人: Alexander Routh
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=GR%2FT28942%2F02
• 关键词: Encapsulated; chemical; biological; catalysts

We propose to synthesise a novel particle, which encapsulates a biologically active enzyme. An aqueous core of a few microns will be surrounded with a titania shell made up of particles of about 30 nm in size. These particles will be driven to the edge of the aqueous drop by an electrostatic driving force created by the stabilising surfactant. The entire particle will then be encased in a polymer shell, created by deposition from an external phase. After manufacture, necessarily in an organic media, the particles can be transferred into any desired supporting media.After demonstrating manufacture of these particles, the next stage of the project will be to examine the biological activity. Regimes of mass or reaction transfer limited reaction are expected. Glucose oxidase enzymes have a cofactor (flavin adenine dinucleotide) that is attached to the enzyme and these will reduce dissolved oxygen to hydrogen peroxide. Other enzymes, such as alcohol dehydrogenase have a co-factor (NAD), which is not attached, and as such leaching experiments will form an important area of study.

我们建议合成一种新型颗粒，其中封装有生物活性酶。几微米的水核将被由尺寸约为 30 nm 的颗粒组成的二氧化钛壳包围。这些颗粒将被稳定表面活性剂产生的静电驱动力驱动到水滴的边缘。然后，整个颗粒将被包裹在通过外相沉积而形成的聚合物壳中。制造后，必须在有机介质中，颗粒可以转移到任何所需的支持介质中。在演示这些颗粒的制造后，该项目的下一阶段将是检查生物活性。预期质量或反应转移限制反应的状态。葡萄糖氧化酶有一个附着在酶上的辅助因子（黄素腺嘌呤二核苷酸），这些因子会将溶解氧还原成过氧化氢。其他酶，例如乙醇脱氢酶，具有不附着的辅因子（NAD），因此浸出实验将形成一个重要的研究领域。

项目成果

Microcapsule flow behaviour in porous media

• DOI: 10.1016/j.ces.2013.08.028
• 发表时间: 2013-10-11
• 期刊: CHEMICAL ENGINEERING SCIENCE
• 影响因子: 4.7
• 作者: Gun, Wei Jin;Routh, Alexander F.
• 通讯作者: Routh, Alexander F.

Flow of pH-responsive microcapsules in porous media

pH 响应微胶囊在多孔介质中的流动

• DOI: 10.1016/j.ces.2014.11.009
• 发表时间: 2015
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: Gun W

Fabrication of colloidosomes at low temperature for the encapsulation of thermally sensitive compounds

• DOI: 10.1016/j.jcis.2007.09.019
• 发表时间: 2008-01-01
• 期刊: JOURNAL OF COLLOID AND INTERFACE SCIENCE
• 影响因子: 9.9
• 作者: Laib, Sarnia;Routh, Alexander F.
• 通讯作者: Routh, Alexander F.