Interdisciplinary Training Program Muscle Biology

描述（由申请人提供）：该计划提供肌肉生物学的跨学科培训，为前和博士后学生。该计划强调骨骼肌，心肌和平滑肌的功能，结构和分子特性。我们的16名教师来自4个基础科学部门和两个跨部门的学位授予计划，在医学院，马里兰州巴尔的摩大学，和2个部门在马里兰州生物技术研究所的大学。附属教师也来自工程学院在我们的姐妹校区，马里兰州巴尔的摩县大学的1个部门。受训人员来自所有参与部门和方案。反映我们的教师背景的多样性，提供的培训将从肌肉发育的分子生物学决定因素和肌肉蛋白质的结构和功能的分子方面，通过肌肉细胞骨架和基质的细胞生物学方面，个体肌肉细胞功能的生物物理和生理分析以及整个肌肉和肌肉器官的生物力学特性。我们的教师在肌肉功能和肌肉细胞骨架和基质的钙控制领域得到国内和国际认可。我们的学生将在这些和各种相关领域接受培训，重点是使用几种补充技术来解决每个调查中的问题。The：博士前培训的主要教学方面将是两个为期一学期的跨学科肌肉课程，这些课程已经由计划教师定期提供，并受到过去学生群体的好评。i我们建议开始更新期，第一年和第二年有4名博士前学员，以增加！在第三、第四和第五年，将博士预科生的人数增加到5人，开始时，将有6名博士后学员，并在整个授予期内保持这一水平。进入博士前培训生将继续在生物，化学和/或物理，优秀的GRE成绩和强有力的推荐信坚实的背景。入职的博士后学员将完成扎实的博士论文，并有强有力的推荐信。该计划的学员将准备采取各种方法来回答肌肉生物学中的基本问题，以及肌肉疾病及其可能的治疗或最终治愈的基础。因此，该计划满足了国家对肌肉功能和疾病的多学科研究人员的需求。

DESCRIPTION (provided by applicant): This program provides interdisciplinary training in muscle biology for pre- and postdoctoral students. The program emphasizes the functional, structural and molecular properties of skeletal, cardiac and smooth muscle. Our 16 faculty members come from 4 basic science departments and two interdepartmental degree granting programs at the School of Medicine, University of Maryland at Baltimore, and 2 departments in the University of Maryland Biotechnology Institute. Affiliate faculty also come from 1 department in the College of Engineering at our sister campus, University of Maryland Baltimore County. Trainees are drawn from all of the participating departments and programs. Reflecting our diversity of faculty backgrounds, the training offered will range from the molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle cytoskeleton and matrix, biophysical and physiological analysis of individual muscle cell function and biomechanical properties of whole muscles and muscular organs. Our faculty is nationally and internationally recognized in the areas of calcium control of muscle function and muscle cytoskeleton and matrix. Our students will receive training in these and in a variety of related areas, with emphasis on the use of several complimentary techniques to approach each question under investigation. The: major didactic aspect of the pre-doctoral training will be two one-semester interdisciplinary courses on muscle that are already regularly offered by the program faculty and which have been well received by past student groups. i We propose to begin the renewal period with 4 pre-doctoral trainees in the first and second years, to increase! to 5 pre-docs in the third, fourth and fifth year and to begin with 6 postdoctoral trainees and maintain that level throughout the granting period. Entering pre-doctoral trainees will continue to have a solid background in biology, chemistry and/or physics, excellent GRE scores and strong letters of recommendation. Incoming]' postdoctoral trainees will have completed a solid PhD thesis and have strong letters of recommendation.! Trainees from this program will be prepared to bring a wide range of approaches to bear on answering basic questions in muscle biology and on the bases for muscle diseases and their possible treatment or eventual cure. The program therefore serves a national need for competent multi-disciplinary investigators of muscle function and disease.