Interdisciplinary Training Program in Muscle Biology

描述：(摘自申请者的)本计划提供 博士后和博士后肌肉生物学的跨学科训练 学生们。该程序强调骨骼、心脏的功能特性 和光滑的肌肉。18名初级教职员工来自该大学的4个系 马里兰大学医学院巴尔的摩分校和巴尔的摩的2个分校 马里兰大学生物技术研究所与来自 巴尔的摩县马里兰大学工程学院。反思 这种师资背景的多样性，培训机会涵盖范围很广 范围包括：肌肉细胞骨架的分子生物学决定因素 并对基质、生物物理和生理功能进行了分析。 单个肌肉细胞、整体肌肉和肌肉的生物力学特性 器官，以及每种治疗肌肉疾病的方法之间的关系。这个 教职人员在肌肉功能和肌肉的钙控制领域工作 细胞骨架和基质。学生们将接受这些方面的培训和 各种相关领域，包括肌肉的分子和功能控制 基因表达，重点是使用几种互补的技术 处理调查中的每一个问题。的主要方面。 教学训练已经包括了两门跨学科的肌肉课程 由项目教职员工提供。 他们推荐了4名博士后和5名博士后实习生参加第一和第二期培训。 续订计划的年份，然后是5前和6前的稳定状态 三至五年级的博士后实习生。进入博士后 实习生将具有生物、化学和/或物理背景，优秀 GRE成绩，研究经验和强有力的推荐信。来电 博士后实习生将完成扎实的博士论文，并拥有强大的 推荐信。该应用程序具有重大和实质性的 科学价值。建议在五年内提供支持，但会减少 在预算中，评级为杰出。

DESCRIPTION: (Taken from the applicant's) This program provides interdisciplinary training in muscle biology for pre- and postdoctoral students. The program emphasizes the functional properties of skeletal, cardiac and smooth muscle. The 18 primary faculty members are from 4 departments at the University of Maryland School of Medicine, Baltimore, and the 2 Baltimore units of the University of Maryland Biotechnology Institute, with affiliates from the College of Engineering, University of Maryland Baltimore County. Reflecting this diversity of faculty backgrounds, the training opportunities cover a wide range and include: the molecular biological determinants of muscle cytoskeleton and matrix, biophysical and physiological analysis of the function of individual muscle cells, biomechanical properties of whole muscles and muscular organs, and the relationship of each of these approaches to muscle disease. The faculty work in the areas of calcium control of muscle function and muscle cytoskeletal and matrix. The students will receive training in these and a variety of related areas, including molecular and functional control of muscle gene expression, with emphasis on the use of several complementary techniques to approach each question under investigation. The major aspects of the didactic training consists of two interdisciplinary courses on muscle already offered by program faculty. They propose 4 predoctoral and 5 postdoctoral trainees for the first and second renewal year of the program, and then a steady state of 5 pre- and 6 postdoctoral trainees in the third through fifth years. Entering predoctoral trainees will have a background in biology, chemistry and/or physics, excellent GRE scores, research experience and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid Ph.D. thesis and have strong letters of recommendation. The application has significant and substantial scientific merit. Support is recommended for the five years, with a reduction in the budget, with a rating of outstanding.