Chromosome Metabolism and Cancer Training Grant

染色体代谢和癌症培训补助金

• 批准号: 7799215
• 负责人: Jonathan A Cooper
• 金额: $ 26.54万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7799215
• 关键词: Chromosomes; Grant; Malignant Neoplasms; Metabolism; Training

This application seeks continuing support for the on-going Chromosome Metabolism and Cancer Training Program that trains researchers exploring the links between chromosome metabolism andcancer. Advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism (gene expression, chromatin assembly, segregation, telomeres and centromeres, DNA repair, etc.) and illustrated its importance in cancer initiation and progression. The 25 training faculty are experts in this area from the Basic Sciences Human Biology Divisions of the Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly and yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists with creative approaches to understanding cancer mechanisms. Two predoctoral positions are requested to maintain the current level of support of this successful program that was initiated ten years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will also be maintained at the current level of five. Predoctoral trainees will be recruited among the MCB students, who enter the PhD program through vigorous competition and are among the best in the nation. Postdoctoral trainees are drawn from an outstanding pool of fellows working with CMTP Faculty. Predoctoral students are appointed to the training grant after they have chosen a permanent laboratory and completed lab rotations and a portion of their required coursework. Postdoctoral training consists of independent research, supplemented by rigorous quarterly presentations in front of training grant faculty and experience in organizing CMTP-sponsored seminars. In addition, all trainees will benefit from the rich activities available for researchers at this Center, including the strong interdisciplinary programs that expose basic scientists to clinical and public health aspects of cancer. It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention.

本申请寻求对正在进行的染色体代谢和癌症研究的持续支持 培训研究人员探索染色体代谢与癌症之间联系的培训计划。 基因和基因组研究的进展极大地促进了对染色体的理解 新陈代谢（基因表达、染色质组装、分离、端粒和着丝粒、DNA 修复、 等）并说明了其在癌症发生和进展中的重要性。 25名培训教师都是以下领域的专家 该领域来自 Fred Hutchinson 癌症研究基础科学人类生物学部门 中心。他们中的许多人都是各自领域的顶尖科学家，他们共同组成了一个有凝聚力的团队， 从不同但互补的角度处理这个问题。他们还包括结构生物学家 分子和细胞生物学家，并利用各种模式生物，如线虫、苍蝇和酵母 他们的研究中除了脊椎动物和培养细胞外。该计划的广度和深度应该会有所帮助 培养具有创造性方法来理解癌症机制的优秀年轻科学家。 需要两个博士前职位来维持这一成功的当前支持水平 该计划于十年前分子与细胞生物学 (MCB) 成立后启动 研究生课程。博士后职位也将维持目前的5个水平。 MCB学生中将招收博士前培训生，通过以下方式进入博士项目： 竞争激烈，在全国名列前茅。博士后培训生均来自 与 CMTP 教员一起工作的优秀研究员库。指定博士生参加培训 在他们选择一个永久实验室并完成实验室轮换和部分实验室后授予 所需的课程作业。博士后培养以独立研究为主，严谨的研究为辅。 每季度在培训补助金教师面前进行演示以及组织 CMTP 赞助的经验 研讨会。此外，所有学员都将受益于该中心为研究人员提供的丰富活动， 包括让基础科学家接触临床和公共卫生的强大跨学科项目 癌症的各个方面。希望这个项目能够培养出对这一领域有深入了解的年轻科学家。 染色体代谢并致力于探索其与癌症病因、治疗和预防的各种联系。