Chromosome Metabolism and Cancer Training Grant

此应用程序寻求对正在进行的染色体代谢和癌症的持续支持 培训计划，培训研究人员探索染色体新陈代谢和癌症之间的联系。 基因和基因组研究的进展极大地促进了对染色体的理解。 代谢(基因表达、染色质组装、分离、端粒和着丝粒、DNA修复、 等)并阐明了它在癌症发生和发展中的重要性。这25名培训教师都是 这一领域来自弗雷德·哈钦森癌症研究的基础科学人类生物学分部 中心。许多人都是各自领域的顶尖科学家，他们共同组成了一个具有凝聚力的团体， 从不同但相辅相成的角度处理这一问题。此外，他们还包括结构生物学家 分子和细胞生物学家，并利用各种模式生物，如线虫，苍蝇和酵母在 除了脊椎动物和他们研究中的培养细胞。这个项目的广度和深度应该会有所帮助 培养优秀的年轻科学家，以创造性的方法了解癌症的机制。 请设2个博士前职位，以维持目前的支持水平 十年前随着分子和细胞生物学(MCB)的形成而启动的计划 研究生课程。博士后职位也将维持目前的5个水平。 博士后实习生将从通过以下途径进入博士生计划的MCB学生中招募 竞争激烈，在全国名列前茅。博士后实习生来自 与CMTP学院合作的杰出研究员池。博士前学生被指派参加培训 在他们选择了永久实验室并完成了实验室轮换和他们的部分 必修课程。博士后培训由独立研究组成，并辅之以严格的 在培训基金教职员工面前进行季度演示，以及组织CMTP赞助的经验 研讨会。此外，所有受训人员都将受益于该中心为研究人员提供的丰富活动， 包括让基础科学家接触临床和公共卫生的强有力的跨学科计划 癌症的各个方面。希望这一计划能培养出对 染色体代谢和致力于探索其与癌症病因、治疗和预防的各种联系。

This application seeks continuing support for the on-going Chromosome Metabolism and Cancer Training Program that trains researchers exploring the links between chromosome metabolism andcancer. Advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism (gene expression, chromatin assembly, segregation, telomeres and centromeres, DNA repair, etc.) and illustrated its importance in cancer initiation and progression. The 25 training faculty are experts in this area from the Basic Sciences Human Biology Divisions of the Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly and yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists with creative approaches to understanding cancer mechanisms. Two predoctoral positions are requested to maintain the current level of support of this successful program that was initiated ten years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will also be maintained at the current level of five. Predoctoral trainees will be recruited among the MCB students, who enter the PhD program through vigorous competition and are among the best in the nation. Postdoctoral trainees are drawn from an outstanding pool of fellows working with CMTP Faculty. Predoctoral students are appointed to the training grant after they have chosen a permanent laboratory and completed lab rotations and a portion of their required coursework. Postdoctoral training consists of independent research, supplemented by rigorous quarterly presentations in front of training grant faculty and experience in organizing CMTP-sponsored seminars. In addition, all trainees will benefit from the rich activities available for researchers at this Center, including the strong interdisciplinary programs that expose basic scientists to clinical and public health aspects of cancer. It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention.