Receptor Tyrosine Kinases: Biology and Cancer

受体酪氨酸激酶：生物学和癌症

• 批准号: 7916135
• 负责人: Jonathan A Cooper
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916135
• 关键词: Academia; Address; Advertising; Animals; Area; Brain; Cancer Biology; Cell Proliferation; Cell physiology; Cell surface; Cells; Cellular biology; Chemotherapy-Oncologic Procedure; Conflict (Psychology); Development; Drug Delivery Systems; Embryonic Development; Ensure; Family; Fees; Female; Financial Support; Funding; Goals; Grant; Industry; International; Malignant Neoplasms; Nervous system structure; Neurons; Neurosciences; Organ; Participant; Play; Protein Tyrosine Kinase; Proteins; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Staging; Students; System; Therapeutic; Therapeutic Intervention; Time; Tissues; Travel; Tyrosine; abstracting; cancer cell; career; cost; extracellular; graduate student; improved; interest; male; meetings; migration; outreach; posters; public health relevance; receptor; success; symposium

DESCRIPTION (provided by applicant): We are seeking partial support for FASEB Summer Research Conferences entitled "Receptor Tyrosine Kinases: Biology and Cancer", to be held June 27 - July 2 2010 and again in June 2012. Such a conference is timely because of exciting recent developments in receptor cross talk, therapeutic advances, and deeper understanding of Receptor Tyrosine Kinases (RTKs) in the brain and development. The planned conferences follow a series of five FASEB conferences on RTKs that were held between 1999 and 2007. RTKs are important in many aspects of animal cell biology, including development, neuroscience and cancer. Previous conferences had an emphasis on RTKs of the Met and ErbB families, and the conferences had seen a dwindling attendance over the years. We have taken several steps to revitalize the meetings. First, while retaining an emphasis on RTKs and cancer, we have widened the scope of the meeting to include other RTKs, other signaling mechanisms, new advances in therapeutic interventions and developmental and neuronal systems in which RTKs play a major role. This broader scope is expected to attract participants with more diverse interests than previously. Second, we have rescheduled the meetings to even numbered years. The previous timing generated conflicts with two other conferences, one sponsored by FASEB and one by Cold Spring Harbor, which addressed similar topics to the RTK conference. These changes, combined with improved advertising and outreach, and an exciting slate of speakers, will boost attendance and ensure the success of the new meetings. FASEB Conferences are small (100-150 participants) meetings held in intimate settings that maximize interactions between senior and junior scientists from academia and industry. In addition to invited speakers, we will intersperse the plenary sessions with short talks selected from the abstracts. 22 of the 33 invited speakers have not presented at this conference ever or in the last 5 years. They include a healthy mix of established and newly-independent investigators, male and female, national and international, addressing basic and applied issues in RTK Biology and Cancer. Refreshments will be provided at the poster sessions to encourage full participation. Financial support is requested to offset travel costs for invited speakers and to fund the travel costs and conference fees for 4 graduate student or postdoctoral level conferees. With this support, we anticipate that the conference will succeed in its goal of promoting scientific exchange and stimulating new research in this important area. PUBLIC HEALTH RELEVANCE: This grant requests funding to partly support conferences focused on the roles of RTKs in normal biology and cancer. Receptor tyrosine kinases (RTKs) are molecules on the cell surface that receive signals from the outside and transmit them to the inside of the cell. They share an enzymatic activity that allows them to phosphorylate cell proteins on tyrosine when their extracellular regions are stimulated. There are many different RTKs in animal cells, and the particular RTKs that are expressed by a cell are important for the normal functions of that cell and the organization of tissues during development. In the nervous system, RTKs respond to signals that guide neuronal connections and ensure their survival. During embryonic development, RTKs help coordinate tissue and organ development by regulating cell proliferation, migration and differentiation. RTKs are frequently abnormal in cancer cells. RTKs are also important drug targets for cancer chemotherapy. The conferences will be open to scientists at all stages of their careers, and funding is sought to offset the travel costs of invited speakers and also of 4 student or postdoctoral participants.

描述（由申请人提供）：我们正在寻求FASEB夏季研究会议的部分支持，题为“受体酪氨酸激酶：生物学和癌症”，将于2010年6月27日至7月2日和2012年6月再次举行。这样的会议是及时的，因为令人兴奋的受体串扰，治疗进展，以及更深入地了解受体酪氨酸激酶（RTK）在大脑和发育的最新发展。计划中的会议是在1999年至2007年期间举行的五次FASEB RTK会议之后举行的。RTK在动物细胞生物学的许多方面都很重要，包括发育，神经科学和癌症。以前的会议重点关注Met和ErbB家族的RTK，多年来会议的出席人数不断减少。我们已采取若干步骤来振兴这些会议。首先，在继续强调RTK和癌症的同时，我们扩大了会议的范围，包括其他RTK，其他信号传导机制，治疗干预的新进展以及RTK发挥主要作用的发育和神经系统。这一更广泛的范围预计将吸引比以前兴趣更广泛的参与者。第二，我们重新安排了会议的日期，将会议改为偶数年举行。之前的时间安排与另外两个会议产生了冲突，一个是由FASEB赞助的，另一个是由冷泉港赞助的，它们讨论了与RTK会议类似的主题。这些变化，加上广告和外联工作的改进，以及令人兴奋的发言者名单，将提高出席率，确保新会议的成功。FASEB会议是小型（100-150名参与者）会议，在亲密的环境中举行，最大限度地提高学术界和工业界高级和初级科学家之间的互动。除了特邀演讲者，我们将穿插从摘要中选出的简短演讲。在33位受邀演讲者中，有22位从未或在过去5年内参加过本次会议。他们包括一个健康的混合建立和新的独立的调查人员，男性和女性，国家和国际，解决RTK生物学和癌症的基本和应用问题。海报展览会上将提供茶点，以鼓励大家踊跃参与。请求提供财政支助，以抵消应邀演讲者的旅费，并为4名研究生或博士后级别的与会者提供旅费和会议费。在这种支持下，我们预计会议将成功地实现其促进科学交流和刺激这一重要领域新研究的目标。 公共卫生相关性：该拨款要求提供资金，部分支持关注RTK在正常生物学和癌症中的作用的会议。受体酪氨酸激酶（RTK）是细胞表面上的分子，其接收来自外部的信号并将其传递到细胞内部。它们共有一种酶活性，当它们的胞外区域受到刺激时，这种酶活性使它们能够磷酸化酪氨酸上的细胞蛋白。在动物细胞中存在许多不同的RTK，并且由细胞表达的特定RTK对于该细胞的正常功能和发育期间组织的组织是重要的。在神经系统中，RTK对引导神经元连接并确保其存活的信号做出反应。在胚胎发育期间，RTK通过调节细胞增殖、迁移和分化来帮助协调组织和器官发育。RTK在癌细胞中经常是异常的。RTK也是癌症化疗的重要药物靶标。会议将向处于职业生涯各个阶段的科学家开放，并寻求资金来抵消受邀演讲者以及4名学生或博士后与会者的差旅费。