Receptor Tyrosine Kinases: Biology and Cancer

受体酪氨酸激酶：生物学和癌症

• 批准号: 7916135
• 负责人: Jonathan A Cooper
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916135
• 关键词: Academia; Address; Advertising; Animals; Area; Brain; Cancer Biology; Cell Proliferation; Cell physiology; Cell surface; Cells; Cellular biology; Chemotherapy-Oncologic Procedure; Conflict (Psychology); Development; Drug Delivery Systems; Embryonic Development; Ensure; Family; Fees; Female; Financial Support; Funding; Goals; Grant; Industry; International; Malignant Neoplasms; Nervous system structure; Neurons; Neurosciences; Organ; Participant; Play; Protein Tyrosine Kinase; Proteins; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Staging; Students; System; Therapeutic; Therapeutic Intervention; Time; Tissues; Travel; Tyrosine; abstracting; cancer cell; career; cost; extracellular; graduate student; improved; interest; male; meetings; migration; outreach; posters; public health relevance; receptor; success; symposium

DESCRIPTION (provided by applicant): We are seeking partial support for FASEB Summer Research Conferences entitled "Receptor Tyrosine Kinases: Biology and Cancer", to be held June 27 - July 2 2010 and again in June 2012. Such a conference is timely because of exciting recent developments in receptor cross talk, therapeutic advances, and deeper understanding of Receptor Tyrosine Kinases (RTKs) in the brain and development. The planned conferences follow a series of five FASEB conferences on RTKs that were held between 1999 and 2007. RTKs are important in many aspects of animal cell biology, including development, neuroscience and cancer. Previous conferences had an emphasis on RTKs of the Met and ErbB families, and the conferences had seen a dwindling attendance over the years. We have taken several steps to revitalize the meetings. First, while retaining an emphasis on RTKs and cancer, we have widened the scope of the meeting to include other RTKs, other signaling mechanisms, new advances in therapeutic interventions and developmental and neuronal systems in which RTKs play a major role. This broader scope is expected to attract participants with more diverse interests than previously. Second, we have rescheduled the meetings to even numbered years. The previous timing generated conflicts with two other conferences, one sponsored by FASEB and one by Cold Spring Harbor, which addressed similar topics to the RTK conference. These changes, combined with improved advertising and outreach, and an exciting slate of speakers, will boost attendance and ensure the success of the new meetings. FASEB Conferences are small (100-150 participants) meetings held in intimate settings that maximize interactions between senior and junior scientists from academia and industry. In addition to invited speakers, we will intersperse the plenary sessions with short talks selected from the abstracts. 22 of the 33 invited speakers have not presented at this conference ever or in the last 5 years. They include a healthy mix of established and newly-independent investigators, male and female, national and international, addressing basic and applied issues in RTK Biology and Cancer. Refreshments will be provided at the poster sessions to encourage full participation. Financial support is requested to offset travel costs for invited speakers and to fund the travel costs and conference fees for 4 graduate student or postdoctoral level conferees. With this support, we anticipate that the conference will succeed in its goal of promoting scientific exchange and stimulating new research in this important area. PUBLIC HEALTH RELEVANCE: This grant requests funding to partly support conferences focused on the roles of RTKs in normal biology and cancer. Receptor tyrosine kinases (RTKs) are molecules on the cell surface that receive signals from the outside and transmit them to the inside of the cell. They share an enzymatic activity that allows them to phosphorylate cell proteins on tyrosine when their extracellular regions are stimulated. There are many different RTKs in animal cells, and the particular RTKs that are expressed by a cell are important for the normal functions of that cell and the organization of tissues during development. In the nervous system, RTKs respond to signals that guide neuronal connections and ensure their survival. During embryonic development, RTKs help coordinate tissue and organ development by regulating cell proliferation, migration and differentiation. RTKs are frequently abnormal in cancer cells. RTKs are also important drug targets for cancer chemotherapy. The conferences will be open to scientists at all stages of their careers, and funding is sought to offset the travel costs of invited speakers and also of 4 student or postdoctoral participants.

描述（由申请人提供）：我们正在为题为“受体酪氨酸激酶：生物学与癌症”的 FASEB 夏季研究会议寻求部分支持，该会议将于 2010 年 6 月 27 日至 7 月 2 日举行，并于 2012 年 6 月再次举行。由于受体串扰、治疗进展以及对大脑和发育中的受体酪氨酸激酶 (RTK) 的更深入了解的最新发展令人兴奋，因此这次会议是及时的。计划中的会议是在 1999 年至 2007 年间举行的五次 FASEB 系列 RTK 会议之后举行的。RTK 在动物细胞生物学的许多方面都很重要，包括发育、神经科学和癌症。以前的会议重点关注 Met 和 ErbB 家族的 RTK，但多年来，会议的出席人数不断减少。我们已采取多项措施来振兴会议。首先，在保留对 RTK 和癌症的重视的同时，我们扩大了会议的范围，以包括其他 RTK、其他信号机制、治疗干预的新进展以及 RTK 在其中发挥主要作用的发育和神经系统。这一更广泛的范围预计将吸引比以前更多样化兴趣的参与者。其次，我们将会议重新安排在偶数年。之前的时间安排与另外两个会议产生了冲突，一个由 FASEB 主办，另一个由 Cold Spring Harbor 主办，这两个会议讨论的主题与 RTK 会议类似。这些变化，加上改进的广告和宣传以及令人兴奋的演讲者名单，将提高出席率并确保新会议的成功。 FASEB 会议是小型（100-150 名参与者）会议，在私密的环境中举行，最大限度地提高学术界和工业界高级和初级科学家之间的互动。除了受邀演讲者外，我们还将在全体会议中穿插从摘要中选出的简短演讲。 33 位受邀演讲者中有 22 位从未在本次会议上或在过去 5 年中发表过演讲。他们包括成熟的和新独立的研究人员、男性和女性、国内和国际的健康组合，解决 RTK 生物学和癌症的基本和应用问题。海报会议期间将提供茶点以鼓励充分参与。请求财政支持来抵消受邀演讲者的差旅费以及 4 名研究生或博士后级别参会者的差旅费和会议费。有了这种支持，我们预计会议将成功实现促进科学交流和激发这一重要领域新研究的目标。 公共卫生相关性：该赠款要求提供部分资金支持关注 RTK 在正常生物学和癌症中的作用的会议。受体酪氨酸激酶 (RTK) 是细胞表面的分子，接收外部信号并将其传输到细胞内部。它们具有共同的酶活性，当细胞外区域受到刺激时，它们可以使细胞蛋白在酪氨酸上磷酸化。动物细胞中有许多不同的 RTK，细胞表达的特定 RTK 对于细胞的正常功能和发育过程中的组织组织非常重要。在神经系统中，RTK 对指导神经元连接的信号做出反应并确保其生存。在胚胎发育过程中，RTK 通过调节细胞增殖、迁移和分化来帮助协调组织和器官发育。 RTK 在癌细胞中经常出现异常。 RTK 也是癌症化疗的重要药物靶点。这些会议将向处于职业生涯各个阶段的科学家开放，并寻求资金来抵消受邀演讲者以及 4 名学生或博士后参与者的旅行费用。