Receptor Tyrosine Kinases: Biology and Cancer

受体酪氨酸激酶：生物学和癌症

• 批准号: 7916135
• 负责人: Jonathan A Cooper
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916135
• 关键词: Academia; Address; Advertising; Animals; Area; Brain; Cancer Biology; Cell Proliferation; Cell physiology; Cell surface; Cells; Cellular biology; Chemotherapy-Oncologic Procedure; Conflict (Psychology); Development; Drug Delivery Systems; Embryonic Development; Ensure; Family; Fees; Female; Financial Support; Funding; Goals; Grant; Industry; International; Malignant Neoplasms; Nervous system structure; Neurons; Neurosciences; Organ; Participant; Play; Protein Tyrosine Kinase; Proteins; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Staging; Students; System; Therapeutic; Therapeutic Intervention; Time; Tissues; Travel; Tyrosine; abstracting; cancer cell; career; cost; extracellular; graduate student; improved; interest; male; meetings; migration; outreach; posters; public health relevance; receptor; success; symposium

DESCRIPTION (provided by applicant): We are seeking partial support for FASEB Summer Research Conferences entitled "Receptor Tyrosine Kinases: Biology and Cancer", to be held June 27 - July 2 2010 and again in June 2012. Such a conference is timely because of exciting recent developments in receptor cross talk, therapeutic advances, and deeper understanding of Receptor Tyrosine Kinases (RTKs) in the brain and development. The planned conferences follow a series of five FASEB conferences on RTKs that were held between 1999 and 2007. RTKs are important in many aspects of animal cell biology, including development, neuroscience and cancer. Previous conferences had an emphasis on RTKs of the Met and ErbB families, and the conferences had seen a dwindling attendance over the years. We have taken several steps to revitalize the meetings. First, while retaining an emphasis on RTKs and cancer, we have widened the scope of the meeting to include other RTKs, other signaling mechanisms, new advances in therapeutic interventions and developmental and neuronal systems in which RTKs play a major role. This broader scope is expected to attract participants with more diverse interests than previously. Second, we have rescheduled the meetings to even numbered years. The previous timing generated conflicts with two other conferences, one sponsored by FASEB and one by Cold Spring Harbor, which addressed similar topics to the RTK conference. These changes, combined with improved advertising and outreach, and an exciting slate of speakers, will boost attendance and ensure the success of the new meetings. FASEB Conferences are small (100-150 participants) meetings held in intimate settings that maximize interactions between senior and junior scientists from academia and industry. In addition to invited speakers, we will intersperse the plenary sessions with short talks selected from the abstracts. 22 of the 33 invited speakers have not presented at this conference ever or in the last 5 years. They include a healthy mix of established and newly-independent investigators, male and female, national and international, addressing basic and applied issues in RTK Biology and Cancer. Refreshments will be provided at the poster sessions to encourage full participation. Financial support is requested to offset travel costs for invited speakers and to fund the travel costs and conference fees for 4 graduate student or postdoctoral level conferees. With this support, we anticipate that the conference will succeed in its goal of promoting scientific exchange and stimulating new research in this important area. PUBLIC HEALTH RELEVANCE: This grant requests funding to partly support conferences focused on the roles of RTKs in normal biology and cancer. Receptor tyrosine kinases (RTKs) are molecules on the cell surface that receive signals from the outside and transmit them to the inside of the cell. They share an enzymatic activity that allows them to phosphorylate cell proteins on tyrosine when their extracellular regions are stimulated. There are many different RTKs in animal cells, and the particular RTKs that are expressed by a cell are important for the normal functions of that cell and the organization of tissues during development. In the nervous system, RTKs respond to signals that guide neuronal connections and ensure their survival. During embryonic development, RTKs help coordinate tissue and organ development by regulating cell proliferation, migration and differentiation. RTKs are frequently abnormal in cancer cells. RTKs are also important drug targets for cancer chemotherapy. The conferences will be open to scientists at all stages of their careers, and funding is sought to offset the travel costs of invited speakers and also of 4 student or postdoctoral participants.

DESCRIPTION (provided by applicant): We are seeking partial support for FASEB Summer Research Conferences entitled "Receptor Tyrosine Kinases: Biology and Cancer", to be held June 27 - July 2 2010 and again in June 2012. Such a conference is timely because of exciting recent developments in receptor cross talk, therapeutic advances, and deeper understanding of Receptor Tyrosine Kinases (RTKs) in the brain and development.计划的会议遵循1999年至2007年间举行的RTK的五次FaseB会议。RTK在动物细胞生物学的许多方面都很重要，包括发育，神经科学和癌症。以前的会议强调了大都会和Erbb家庭的RTK，多年来，会议的出席人数越来越大。我们已经采取了几个步骤来振兴会议。首先，尽管保留了RTK和癌症的重视，但我们扩大了会议的范围，包括其他RTK，其他信号机制，治疗干预措施的新进展以及RTKS起主要作用的发展和神经元系统。预计这种更广泛的范围将吸引比以前更多样化的参与者。其次，我们将会议重新安排到了数年。以前的时机与另外两个会议产生了冲突，一次是由Faseb赞助的，一个由Cold Spring Harbor发起的，该会议与RTK会议相似。这些变化，加上改进的广告和宣传，以及令人兴奋的演讲者，将提高出勤率并确保新会议的成功。 FaseB会议是在亲密环境中举行的小型（100-150名参与者）会议，可最大程度地提高学术界和工业的高级科学家之间的互动。除了被邀请的演讲者外，我们还将与从摘要中选择的简短演讲中插入全体会议。在过去或过去5年中，在这次会议上没有在33名受邀发言人中有22位。其中包括男性和女性，国家和国际的既定和新独立研究人员的健康组合，解决了RTK生物学和癌症中的基本和应用问题。将在海报会议上提供茶点，以鼓励完全参与。请求财政支持以抵消受邀发言人的旅行费用，并为4名研究生或博士后级别的同事提供旅行费用和会议费。在这一支持下，我们预计会议将成功地促进科学交流并刺激这一重要领域的新研究。 公共卫生相关性：该赠款要求资助部分支持RTK在正常生物学和癌症中的作用。受体酪氨酸激酶（RTK）是细胞表面上接收信号并将其传递到细胞内部的分子。它们具有一种酶促活性，使它们在刺激细胞外区域时可以在酪氨酸上磷酸化细胞蛋白。动物细胞中有许多不同的RTK，由细胞表达的特定RTK对于该细胞的正常功能和发育过程中组织的组织至关重要。在神经系统中，RTK响应指导神经元连接并确保其生存的信号。在胚胎发育过程中，RTK通过调节细胞增殖，迁移和分化来帮助协调组织和器官发育。 RTK经常在癌细胞中异常。 RTK也是癌症化学疗法的重要药物靶标。这些会议将在其职业生涯的各个阶段向科学家开放，并寻求资金来抵消受邀演讲者以及4名学生或博士后参与者的旅行费用。