Cognitive Speed of Processing Training Among Persons with Parkinson?s Disease

帕金森病患者处理训练的认知速度

• 批准号: 7915655
• 负责人: Jerri Edwards
• 金额: $ 14.44万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915655
• 关键词: Accounting; Affect; Age; Antidepressive Agents; Automobile Driving; Clinical Trials; Cognition; Cognitive; Control Groups; Data; Dementia; Demographic Factors; Development; Diagnosis; Disease; Dopamine Agonists; Drug Prescriptions; Educational Background; Effectiveness; Elderly; Exclusion Criteria; Functional disorder; Glean; Impaired cognition; Impairment; Individual; Intervention; Investigation; Knowledge; Life; Long-Term Care; Mental Depression; Motor; Onset of illness; Parkinson Disease; Parkinson' s Dementia; Participant; Patients; Performance; Persons; Pharmaceutical Preparations; Population; Population Intervention; Productivity; Protocols documentation; Quality of life; Randomized; Recommendation; Relative (related person); Research; Severities; Speed; Staging; Symptoms; Testing; Time; Training; Training Programs; Training Technics; United States; Vision; base; cognitive function; cognitive training; depressive symptoms; efficacy testing; experience; health related quality of life; illness length; improved; innovation; instrumental activity of daily living; mental state; processing speed; public health relevance; tool

DESCRIPTION (provided by applicant): Parkinson's Disease (PD) affects about 1 million individuals in the United States. In addition to the typical motor dysfunction, PD also affects cognition and vision, even in early stages of the disease, impairing instrumental activities of daily living such as driving. Reduced cognitive speed of processing, or bradyphrenia, strongly contributes to cognitive decline in PD. Recent research has demonstrated that interventions can enhance cognitive speed of processing, protect against further cognitive decline, and improve the everyday functioning of relatively healthy, older adults. However, the potential of such training techniques to enhance cognitive functions among subpopulations with different disease states, such as PD, has not been thoroughly investigated. The proposed study will further examine the feasibility and test the efficacy of a well-established cognitive training tool among individuals in the early stages of PD who have not been diagnosed with dementia. A variety of factors have been found to influence cognitive performance among persons with PD and may moderate their ability to benefit from cognitive training such as age at disease onset, disease duration, manifestiation, severity, and medication use as well as concomitant depression. These factors along with demographic variables will be evaluated as moderators of training benefit. Baseline cognitive assessments will be completed among seventy-five individuals with PD who will be randomized to cognitive training or a treatment-delayed control condition. The efficacy of training to immediately enhance cognitive functioning will be evaulated through a post-training (or equivalent delay) assessment. Disease and demographic factors that may impact the efficiacy of cognitive training for persons with PD will be examined in relation to training gains. Considering that cognitive function among individuals with PD is a strong predictor of everyday functioning and subsequent need for long term care, enhancing cognitive function of individuals with PD through training has great potential to prolong such persons' productivity, independence, and quality of life. The information gained from this study will be useful for identifying individuals with PD who are most likely to benefit from cognitive training as well as the development, refinement, and implementation of appropriate cognitive interventions for this population. PUBLIC HEALTH RELEVANCE: Parkinson's disease affects about 1 million individuals in the United States. The proposed study will pilot test the feasibility of using cognitive speed of processing training among persons with Parkinson's disease to improve cognitive functioning. Enhancing cognitive function of individuals with Parkinson's disease through training has great potential to prolong such persons' productivity, independence, and quality of life.

描述（由申请人提供）：帕金森病（PD）在美国影响约100万人。除了典型的运动功能障碍外，PD还会影响认知和视力，即使在疾病的早期阶段，也会损害日常生活的工具活动，如驾驶。认知处理速度的降低，或精神分裂症，是PD患者认知能力下降的重要原因。最近的研究表明，干预可以提高认知处理的速度，防止进一步的认知衰退，并改善相对健康的老年人的日常功能。然而，这种训练技术在不同疾病状态（如PD）的亚群中增强认知功能的潜力尚未得到彻底的研究。这项拟议的研究将进一步研究一种成熟的认知训练工具在未被诊断为痴呆症的早期PD患者中的可行性和有效性。已经发现多种因素影响PD患者的认知表现，并可能调节他们从认知训练中获益的能力，如疾病发病年龄、疾病持续时间、表现、严重程度、药物使用以及伴随的抑郁症。这些因素以及人口统计变量将作为培训效益的调节因素进行评估。基线认知评估将在75名PD患者中完成，他们将被随机分配到认知训练组或治疗延迟对照组。训练对立即增强认知功能的效果将通过训练后（或同等延迟）评估来评估。疾病和人口因素可能会影响PD患者认知训练的效率，将检查与训练收益的关系。考虑到PD患者的认知功能是日常功能和后续长期护理需求的一个强有力的预测指标，通过训练增强PD患者的认知功能具有极大的潜力，可以延长他们的生产力、独立性和生活质量。从这项研究中获得的信息将有助于识别最有可能从认知训练中受益的PD患者，以及为这一人群开发、改进和实施适当的认知干预措施。公共卫生相关性：帕金森氏症在美国影响着大约100万人。这项拟议的研究将试点测试在帕金森病患者中使用认知处理速度训练来改善认知功能的可行性。通过训练增强帕金森病患者的认知功能，对于延长他们的生产力、独立性和生活质量具有巨大的潜力。

项目成果

Applying the Health Belief Model to Quantify and Investigate Expectations for Computerized Cognitive Training.

• DOI: 10.1007/s41465-020-00183-3
• 发表时间: 2021-03
• 期刊: Journal of cognitive enhancement : towards the integration of theory and practice
• 作者: Edwards JD;Philllips CB;O'Connor ML;O'Brien JL;Hudak EM;Nicholson JS
• 通讯作者: Nicholson JS