Interventions to Attenuate Cognitive Decline
减缓认知衰退的干预措施
基本信息
- 批准号:10087692
- 负责人:
- 金额:$ 29.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAdultAffectAge-associated memory impairmentAlzheimer&aposs DiseaseAttenuatedAuditoryBinauralCognitionCognitiveCognitive agingControl GroupsCorrelation StudiesDataDementiaDiagnosisElderlyFinancial HardshipGoalsHealthImpaired cognitionIndividualInterventionLifeLinkMeasuresMediatingMediationMediator of activation proteinMedicalMemoryMissionMusicNeurosciencesOutcomeOutcome StudyPerformancePhasePilot ProjectsPopulationPrevalencePublic HealthRandomized Clinical TrialsResearchRisk FactorsStructureSymptomsTenuateTrainingUnited States National Institutes of HealthWorkactive controlage relatedauditory processingcognitive abilitycognitive functioncognitive performancedesigndisabilityeffective interventionepidemiologic dataexecutive functionexperimental studyfunctional declinefunctional improvementfunctional outcomesimprovedinnovationintervention effectmild cognitive impairmentnovelnovel strategiespost interventionprocessing speedrandomized trialspeech in noisespeech processingtheories
项目摘要
PROJECT SUMMARY
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engage-
ment, training, or stimulation), but it is not clear which approaches are efficacious. It is also not clear when,
along the continuum of normal cognitive aging to mild cognitive impairment (MCI-a transitional stage before
dementia onset), it is most effective to intervene. Crucially, the underlying mechanisms of effective cognitive in-
terventions are not known; a critical barrier to progress in this field. There is an urgent need to identify effective
approaches to curb the increasing prevalence of dementia. The overall objective is to apply the best cognitive
interventions to attenuate cognitive and functional decline and curb dementia prevalence. The long-term goals
are to promote maintained health and independence among older adults. [This randomized clinical trial will de-
termine the efficacy of a novel cognitive engagement intervention approach (intense piano training) as com-
pared to cognitive stimulation (which will serve as a stringent, active control)]. Grounded in theory, the central
hypothesis is that interventions enhancing central auditory processing (CAP), a strong, longitudinal predictor of
MCI and dementia, will improve cognition. Music training is increasingly recognized as a feasible means to at-
tenuate age-related cognitive decline. Prior research and our preliminary data suggest that intense piano train-
ing may enhance CAP and is likely more effective than cognitive stimulation. [Correlational studies indicate su-
perior CAP, executive function, and other cognitive abilities for adults with formal music training compared to
non-musicians. Our results across three pilot randomized trials show that piano training improves older adults'
CAP and executive function, including those with MCI]. The specific aims of the study are to examine the effi-
cacy of intense piano training relative to cognitive stimulation (active controls) to improve CAP, cognition, and
everyday function among older adults with and without MCI. The efficacy of piano training will be established
and moderating effects of MCI status will be examined. The proposed study further aims to elucidate the un-
derlying mechanisms of effective cognitive intervention approaches by exploring mediators of training gains.
Study outcomes will be identification of effective intervention approaches to attenuate age-related cognitive
and functional decline and elucidation of the mechanisms. The proposed study is innovative, in our opinion, as
the first phase II randomized trial of piano training to enhance older adults' cognition. Moreover, this study is
innovative by including older individuals with and without MCI and assessing effects on everyday functional
performance. Most importantly, to advance this field, we will use mediation analyses to elucidate the underlying
mechanisms of intervention effects. The contributions will be significant, advancing our understanding of how
cognitive interventions produce cognitive and functional change. Results will facilitate improved design and im-
plementation of effective interventions to attenuate cognitive decline and curb the prevalence of dementia,
thereby improving public health.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Dynamic Useful Field of View Training to Enhance Older Adults' Cognitive and Motor Function: A Pilot Study.
- DOI:10.1007/s41465-021-00219-2
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Keys to staying sharp: A randomized clinical trial of piano training among older adults with and without mild cognitive impairment.
保持敏锐的关键:对有或没有轻度认知障碍的老年人进行钢琴训练的随机临床试验。
- DOI:10.1016/j.cct.2019.06.003
- 发表时间:2019
- 期刊:
- 影响因子:2.2
- 作者:Hudak,ElizabethM;Bugos,Jennifer;Andel,Ross;Lister,JenniferJ;Ji,Ming;Edwards,JerriD
- 通讯作者:Edwards,JerriD
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Jerri Edwards其他文献
Jerri Edwards的其他文献
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{{ truncateString('Jerri Edwards', 18)}}的其他基金
Cognitive training to reduce incidence of cognitive impairment in older adults
认知训练可降低老年人认知障碍的发生率
- 批准号:
10334504 - 财政年份:2021
- 资助金额:
$ 29.75万 - 项目类别:
Supplement to Cognitive training to reduce incidence of cognitive impairment in older adults
认知训练的补充可降低老年人认知障碍的发生率
- 批准号:
10517797 - 财政年份:2021
- 资助金额:
$ 29.75万 - 项目类别:
Cognitive training to reduce incidence of cognitive impairment in older adults
认知训练可降低老年人认知障碍的发生率
- 批准号:
10589134 - 财政年份:2021
- 资助金额:
$ 29.75万 - 项目类别:
Planning an Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia
规划认知训练的适应性临床试验以改善功能并延缓痴呆
- 批准号:
9791317 - 财政年份:2018
- 资助金额:
$ 29.75万 - 项目类别:
Cognitive Speed of Processing Training Among Persons with Parkinson?s Disease
帕金森病患者处理训练的认知速度
- 批准号:
7915655 - 财政年份:2009
- 资助金额:
$ 29.75万 - 项目类别:
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