Identifying novel genome instability signatures in cancer

癌症是世界面临的最大的临床问题。癌症的一个潜在标志是细胞遗传信息中错误的积累，这些错误是由基因组不稳定性引起的。该研究项目旨在研究通过我们的筛选鉴定的新型分子，这些分子在癌症中响应基因组不稳定性发挥作用。这项研究预计将确定每个分子在维持基因组稳定性中的作用，并预测患者的诊断和结果。

Cancer is the single biggest clinical problem facing the world. An underlying hallmark of cancer is the accumulation of errors in the genetic information of a cell which arises through genomic instability. This research project aims to investigate novel molecules identified by our screening that function in response to genomic instability in cancer. This study is expected to define roles for each molecule in the maintenance of genomic stability and predict for patient diagnosis and outcome.