Multidisciplinary Training in Cardiovascular Research

描述（由申请人提供）：本提案代表了明尼苏达大学心血管科学研究培训支持的修订竞争性更新申请。该提案的目的是提供严格的心血管科学研究培训，为学术心脏病学或心血管调查的职业生涯做好准备。已经开发了一个全面的课程，包括正式的课程工作，以及密集的实验室经验，在心血管研究的概念和方法提供了坚实的基础。该培训计划旨在提供跨传统学科的多学科研究经验，强调独特的研究方法在心血管科学中具有临床重要性的问题的应用。根据先前的批评意见对该提案进行了修订，以回应审评人员提出的具体问题，并更新提案，增加进一步加强培训方案的机构承诺。除了研究培训外，还特别注意提供实验室数据的书面和口头介绍，研究赠款的准备和指导技能的发展。已经开始临床心脏病学培训的医学博士候选人或选择在开始临床心脏病学培训之前进行为期3年的研究，以及博士后博士候选人将接受为期2-3年的强化研究培训。培训机会已在四个学术主题领域开发：（1）心脏发育和干细胞群再生;（2）分子和综合心血管生理学;（3）核磁共振的心血管应用，以及（4）临床和流行病学研究，导致临床研究理学硕士学位。这些具体的学术主题是根据四个考虑因素选择的：（1）它们是当前研究感兴趣的领域，在知识和理解方面存在着巨大的进步;（2）它们是需要训练有素的调查人员和学术医生的领域;（3）它们是具有显著深度的研究专业知识和设施的领域，并具有稳定的资金，可以在明尼苏达大学提供全面的培训计划，（4）这些领域已经存在跨学科的关系，从而确保学员参与多学科的合作研究。该计划的长期目标是提供一个持续的医生科学家和基础研究人员在心血管科学谁是训练有素的使用国家的最先进的技术来探索重要的研究课题，并成功地竞争独立的赠款资金。

DESCRIPTION (provided by applicant): This proposal represents a revised competitive renewal application for support of research training in cardiovascular science at the University of Minnesota. The aim of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or cardiovascular investigation. A comprehensive curriculum has been developed, including formal course work, as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. The training program has been designed to provide a multidisciplinary research experience crossing traditional disciplines to emphasize application of unique research methodology to problems of clinical importance in cardiovascular science. The proposal has been revised in response to the previous critique to respond to specific questions raised by the reviewers and to update the proposal with additional institutional commitments that further enhance the training program. In addition to research training, special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. MD candidates who have begun their training in clinical cardiology or who elect to perform a 3-year period of research prior to beginning their clinical cardiology training, as well as postdoctoral PhD candidates will be accepted for a 2-3 year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) cardiac development and regeneration from stem cell populations; (2) molecular and integrative cardiovascular physiology; (3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic studies leading to a Master of Science degree in clinical research. These specific academic themes were chosen on the basis of four considerations; (1) they are areas of current research interest in which the potential for great strides in knowledge and understanding exist; (2) they are areas in which there is demand for trained investigators and academic physicians; (3) they are areas in which there is significant depth of research expertise and facilities with stable funding to provide a comprehensive training program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in a multidisciplinary collaborative research experience. The long- term goal of this program is to provide a continuing stream of physician scientists and basic investigators working in cardiovascular science who are trained to use state-of-the-art technology to explore important research topics and successfully compete for independent grant funding.