Multidisciplinary Training in Cardiovascular Research

本提案代表了明尼苏达大学心血管科学研究培训支持的修订竞争性更新申请。这项建议的目的是提供严格的心血管科学研究培训，为学术心脏病学或心血管研究的职业生涯做好准备。已经开发了一个全面的课程，包括正式的课程作业，以及密集的实验室经验，为心血管研究的概念和方法提供坚实的基础。培训计划旨在提供跨传统学科的多学科研究经验，强调将独特的研究方法应用于心血管科学的临床重要问题。针对之前的评论，对提案进行了修订，以回应审稿人提出的具体问题，并更新了提案，增加了进一步加强培训计划的机构承诺。除了研究培训外，还特别注意提供书面和口头实验室数据展示、研究经费准备和指导技能发展方面的指导。已经开始临床心脏病学培训或选择在开始临床心脏病学培训之前进行3年研究的医学博士候选人，以及博士后博士候选人将被接受2-3年的强化研究培训。培训机会已在四个学术主题领域开发：(1)心脏发育和干细胞群体再生；(2)分子与综合心血管生理学；(3)核磁共振在心血管方面的应用；(4)临床和流行病学研究，获得临床研究硕士学位。这些具体的学术主题是基于四个考虑因素选择的；(1)它们是当前研究感兴趣的领域，在这些领域中存在着在知识和理解方面取得巨大进步的潜力；(2)对训练有素的调查人员和学术医师有需求的领域；(3)这些领域具有相当深度的研究专业知识和设施，并有稳定的资金来提供明尼苏达大学的综合培训计划；(4)这些领域已经存在跨学科关系，从而确保学员参与多学科合作研究经验。该项目的长期目标是为从事心血管科学工作的内科科学家和基础研究人员提供源源不断的培训，使他们能够使用最先进的技术探索重要的研究课题，并成功地竞争独立的资助资金。

This proposal represents a revised competitive renewal application for support of research training in cardiovascular science at the University of Minnesota. The aim of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or cardiovascular investigation. A comprehensive curriculum has been developed, including formal course work, as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. The training program has been designed to provide a multidisciplinary research experience crossing traditional disciplines to emphasize application of unique research methodology to problems of clinical importance in cardiovascular science. The proposal has been revised in response to the previous critique to respond to specific questions raised by the reviewers and to update the proposal with additional institutional commitments that further enhance the training program. In addition to research training, special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. MD candidates who have begun their training in clinical cardiology or who elect to perform a 3-year period of research prior to beginning their clinical cardiology training, as well as postdoctoral PhD candidates will be accepted for a 2-3 year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) cardiac development and regeneration from stem cell populations; (2) molecular and integrative cardiovascular physiology; (3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic studies leading to a Master of Science degree in clinical research. These specific academic themes were chosen on the basis of four considerations; (1) they are areas of current research interest in which the potential for great strides in knowledge and understanding exist; (2) they are areas in which there is demand for trained investigators and academic physicians; (3) they are areas in which there is significant depth of research expertise and facilities with stable funding to provide a comprehensive training program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in a multidisciplinary collaborative research experience. The long- term goal of this program is to provide a continuing stream of physician scientists and basic investigators working in cardiovascular science who are trained to use state-of-the-art technology to explore important research topics and successfully compete for independent grant funding.