Multidisciplinary Training in Cardiovascular Research

心血管研究的多学科培训

• 批准号: 8469544
• 负责人: ROBERT James BACHE
• 金额: $ 26.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8469544
• 关键词: Cardiovascular system; Research; Training; multidisciplinary

This proposal represents a revised connpetitive renewal application for support of research training in cardiovascular science at the University of Minnesota. The ainn of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or cardiovascular investigation. A comprehensive curriculum has been developed, including formal course work, as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. The training program has been designed to provide a multidisciplinary research experience crossing traditional disciplines to emphasize application of unique research methodology to problems of clinical importance in cardiovascular science. The proposal has been revised in response to the previous critique to respond to specific questions raised by the reviewers and to update the proposal with additional institutional commitments that further enhance the training program. In addition to research training, special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. MD candidates who have begun their training in clinical cardiology or who elect to perform a 3-year period of research prior to beginning their clinical cardiology training, as well as postdoctoral PhD candidates will be accepted for a 2-3 year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) cardiac development and regeneration from stem cell populations; (2) molecular and integrative cardiovascular physiology; (3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic studies leading to a Master of Science degree in clinical research. These specific academic themes were chosen on the basis of four considerations; (1) they are areas of current research interest in which the potential for great strides in knowledge and understanding exist; (2) they are areas in which there is demand for trained investigators and academic physicians; (3) they are areas in which there is significant depth of research expertise and facilities with stable funding to provide a comprehensive training . program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in a multidisciplinary collaborative research experience. The long- term goal of this program is to provide a continuing stream of physician scientists and basic investigators working in cardiovascular science who are trained to use state-of-the-art technology to explore important research topics and successfully compete for independent grant funding. RELEVANCE (See instructions): This grant is to provide funds for state of the art training of physicians and post doctoral students in cardiovascular research. The aim of the proposal is to supply a continuing stream of scientists working in areas relevant to heart disease.

这项提案是一份修订后的同意性续签申请，要求支持#年的研究培训。 明尼苏达大学心血管科学。这项提议的目的是提供严格的 心血管科学方面的研究培训，为心脏病学术或职业生涯做好准备 心血管疾病调查。制定了一套全面的课程，包括正规课程。 工作，以及密集的实验室经验，为概念和 心血管研究方法论。该培训计划旨在提供 跨传统学科的多学科研究经验，强调独特的应用 心血管科学中临床重要问题的研究方法。这项提议一直是 针对先前的批评进行了修订，以回应审查员提出的具体问题和 用进一步加强培训计划的额外机构承诺更新提案。在……里面 除了研究培训外，还特别注重提供书面和口头报告的指导 实验室数据、研究补助金的准备和指导技能的发展。医学博士候选人 已开始接受临床心脏病学培训或选择在3年前进行研究 开始他们的临床心脏病学培训，以及博士后候选人将被接受2-3 为期一年的强化研究训练。在四个学术领域开发了培训机会 主题领域：(1)干细胞群体的心脏发育和再生；(2)分子和 综合心血管生理学；(3)核磁共振在心血管方面的应用；(4) 临床和流行病学研究导致获得临床研究的理学硕士学位。这些特定的 选择学术主题是基于四个考虑：(1)它们是当前研究的领域 有可能在知识和理解方面大踏步前进的兴趣；(2)它们是 有对训练有素的调查人员和学术医生的需求；(3)它们是有 有相当深度的研究专业知识和设施，并有稳定的资金提供全面的培训。 明尼苏达大学的课程，以及(4)它们是已经有跨学科关系的领域 存在，从而确保受训者参与多学科合作研究体验。长的- 该计划的学期目标是提供源源不断的内科科学家和基础研究人员 在心血管科学工作，他们接受过使用最先进的技术来探索重要的 研究课题，并成功竞争独立的赠款资金。 相关性(请参阅说明)： 这项拨款是为了提供资金，为医生和博士后提供最先进的培训 心血管研究。这项提议的目的是提供源源不断的科学家在 与心脏病相关的领域。

项目成果

Accuracy of heart disease prevalence estimated from claims data compared with an electronic health record.

与电子健康记录相比，根据索赔数据估算的心脏病患病率的准确性。

• DOI: 10.5888/pcd9.120009
• 发表时间: 2012
• 期刊: Preventing chronic disease
• 影响因子: 5.5
• 作者: Kottke TE;Baechler CJ;Parker ED
• 通讯作者: Parker ED

An algorithm that identifies coronary and heart failure events in the electronic health record.

一种识别电子健康记录中的冠心病和心力衰竭事件的算法。

• DOI: 10.5888/pcd10.120097
• 发表时间: 2013
• 期刊: Preventing chronic disease
• 影响因子: 5.5
• 作者: Kottke,ThomasE;Baechler,CourtneyJordan
• 通讯作者: Baechler,CourtneyJordan

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

• DOI: 10.1002/stem.1131
• 发表时间: 2012-08
• 期刊: STEM CELLS
• 影响因子: 5.2
• 作者: Koyano-Nakagawa, Naoko;Kweon, Junghun;Iacovino, Michelina;Shi, Xiaozhong;Rasmussen, Tara L.;Borges, Luciene;Zirbes, Katie M.;Li, Tongbin;Perlingeiro, Rita C. R.;Kyba, Michael;Garry, Daniel J.
• 通讯作者: Garry, Daniel J.

Effect of Sleep-Disordered Breathing on Appropriate Implantable Cardioverter-Defibrillator Therapy in Patients With Heart Failure: A Systematic Review and Meta-Analysis.

• DOI: 10.1161/circep.116.004609
• 发表时间: 2017-03
• 期刊: Circulation. Arrhythmia and electrophysiology
• 作者: Kwon Y;Koene RJ;Kwon O;Kealhofer JV;Adabag S;Duval S
• 通讯作者: Duval S

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling.

• DOI: 10.1161/hypertensionaha.114.03811
• 发表时间: 2014-10
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Liu X;Kwak D;Lu Z;Xu X;Fassett J;Wang H;Wei Y;Cavener DR;Hu X;Hall J;Bache RJ;Chen Y
• 通讯作者: Chen Y