Metalloproteomics: A new piece of the systems biology puzzle

金属蛋白质组学：系统生物学难题的新部分

• 批准号: LP140100095
• 负责人: Dr Blaine Roberts
• 金额: $ 16.22万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100095
• 关键词: Metalloproteomics; new; piece; systems; biology

Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, this project aims to adapt and apply advanced mass spectrometry to the study of metalloproteins, developing new methods for studying hundreds of molecules in single experiments. Using the C. elegans model organism the project aims to showcase the importance of metals in biology and develop new solutions for the $2.9 billion proteomics industry.

系统生物学使用先进的分析技术来研究活细胞的复杂化学。许多细胞功能是涉及金属蛋白的化学反应的结果，众所周知，由于金属和蛋白质之间的弱键通常不符合传统的蛋白质组学方法，金属和蛋白质之间的化学反应很难研究。该项目与领先的分析制造商安捷伦技术公司合作，旨在将先进的质谱学应用于金属蛋白质的研究，开发在单个实验中研究数百个分子的新方法。该项目利用线虫模型生物，旨在展示金属在生物学中的重要性，并为价值29亿美元的蛋白质组学行业开发新的解决方案。