GENIS

杰尼斯

• 批准号: 7960782
• 负责人: Yuan-Xiang Meng
• 金额: $ 1.95万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960782
• 关键词: African American; Beta Cell; Cell physiology; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Development; Diabetes Mellitus; Disease susceptibility; Funding; Genes; Genetic Markers; Glucose; Goals; Grant; Health; Individual; Institution; Insulin; Metabolism; Minority; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Phenotype; Population; Predisposition; Preventive Intervention; Research; Research Personnel; Resources; Risk; Sampling; Source; Susceptibility Gene; United States National Institutes of Health; Variant; base; diabetic patient; epidemiology study; genetic epidemiology; high risk; human TCF7L2 protein; insulin secretion; non-diabetic; zinc-binding protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent large-scale genetic epidemiology studies have identified newly defined susceptibility genes for Type 2 Diabetes. However, the pathobiological mechanisms by which these putative disease susceptibility loci predispose to diabetes remains to be further defined. The goal of the study is to determine whether genetic markers such as DNA variants in the zinc transporter SLC30A8 or the transcription factor 7-like 2 (TCF7L2) genes can be used to identify individuals with increased susceptibility to impaired beta-cell function and the eventual development of diabetes within an at risk African American population (AA). The specific aims are: 1) Establish a well-phenotyped sample of overweight/obese, non-diabetic African-American subjects that undergo careful characterization of glucose/insulin metabolism in the GCRC setting and 2) Determine if variants in SLC308A8 and TCF7L2 genes are associated with impaired insulin secretion in overweight/obese African Americans. These studies should eventually lay the groundwork for 'Predictive Health' models based on genetic markers that will enable clinicians to more effectively identify high-risk pre-diabetic patients and target preventive interventions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 最近的大规模遗传流行病学研究已经确定了新定义的2型糖尿病易感基因。然而，这些假定的疾病易感基因座易患糖尿病的病理生物学机制仍有待进一步确定。这项研究的目的是确定遗传标记，如锌转运蛋白SLC 30 A8或转录因子7样2（TCF 7 L2）基因中的DNA变异，是否可用于识别对β细胞功能受损的易感性增加的个体，并最终在有风险的非洲裔美国人（AA）中发展为糖尿病。具体目标是：1）建立超重/肥胖、非糖尿病非裔美国人受试者的良好表型样品，其在GCRC环境中经历葡萄糖/胰岛素代谢的仔细表征，和2）确定SLC 308 A8和TCF 7 L2基因中的变体是否与超重/肥胖非裔美国人中胰岛素分泌受损相关。这些研究最终将为基于遗传标记的“预测健康”模型奠定基础，使临床医生能够更有效地识别高风险的糖尿病前期患者并进行针对性的预防干预。