T regulatory Cells in HSV Immunity and Immunopathology

HSV 免疫和免疫病理学中的 T 调节细胞

• 批准号: 7760639
• 负责人: Barry T. Rouse
• 金额: $ 33.75万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7760639
• 关键词: Affect; Antigens; Antiviral Agents; Biological Models; Cells; Drug Formulations; Encephalitis; Event; Goals; Grant; Herpes Labialis; Human; IL2RA gene; Immune; Immune response; Immunity; Infection; Infectious Agent; Keratitis; Lesion; Life; Listeria monocytogenes; Measures; Memory; Outcome; Pain; Persons; Phase; Predisposition; Prevention; Public Health; Recurrence; Regulatory T-Lymphocyte; Research; Research Design; Simplexvirus; System; Testing; Tissues; Vaccine Design; Vaccines; Virus; Virus Diseases; base; cell type; immunopathology; in vivo; influenzavirus; mouse model; pathogen; response; superinfection

Herpes simplex virus is a common human pathogen that causes cold sores, fever blisters, keratitis, and encephalitis. Once infected, a person retains the virus life-long and may suffer periodic recurrence of painful lesions that take place under a variety of conditions. Thus, prevention of either primary infections or recurring HSV lesions is an important public health goal. This will likely be achieved by understanding the basic immunity mechanism to HSV infection and applying those strategies to develop effective vaccines. Recently, we observed that in the mouse model system, protective immunity to HSV infection was dampened by a class of regulatory T cells (Treg). Such cells also hampered the efficacy of certain vaccine formulations directed against the virus. However, the same type of cells were beneficial in reducing immunopathological lesions caused by HSV infection. The current proposal will define the circumstancesthat result in Treg induction during primary and recall immunity to HSV infection. We shall also attempt to determine if the Treg response induced by HSV infection impacts on the level of immunity to other superinfections. Finally, a number of different strategies will be used to modulate the function of Treg cells in vivo to either increase immunity to HSV or reduce the damage resulting from HSV-induced immunopathology.

单纯疱疹病毒是一种常见的人类病原体，它会导致唇疱疹、发热水泡、