ISOLATION OF A NEW HIV-2 GROUP IN THE US

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类免疫缺陷病毒2型(HIV-2)是几十年前在西非出现的从煤烟芒果鸟向人类跨物种传播SIV后出现的。HIV-2的流行组是HIV-2 A组和B组。这两个组在人类人口中已经建立了至少50年。然而，新的SIV分化株很可能会感染人类，并导致新的疫情。我们于2008年从一名2007年移民到美国的塞拉利昂免疫缺陷患者身上分离出一种新的HIV-2 F组，HIV2-NWK08F。需要提醒塞拉利昂和其他地方的卫生保健提供者，存在一种艾滋病毒-2毒株，这种毒株不是通过对流行的艾滋病毒-2毒株进行聚合酶链式反应检测到的，可能会导致免疫抑制。这是第一例出现在非洲英语国家的HIV-2病毒。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 2 (HIV-2) emerged following cross-species transmission of SIV from sooty mangabeys to humans several decades ago in West Africa. The epidemic groups of HIV-2 are HIV-2 Group A and Group B. These 2 groups have been established in the human population for at least 50 years. However, it is likely that new divergent strains of SIV can infect humans and lead to new outbreaks. We isolated characterized a new HIV-2 group F, HIV2-NWK08F, in 2008 from an immunodeficient person from Sierra Leone who immigrated to the USA in 2007. Health care providers in Sierra Leone and elsewhere need to be alerted that a strain of HIV-2, which is not detected by PCR for epidemic HIV-2 strains, exists and can lead to immunosuppression. This is the first HIV-2 to emerge from an Anglophone African country.