ISOLATION OF A NEW HIV-2 GROUP IN THE US

美国隔离新的 HIV-2 群体

• 批准号: 8173028
• 负责人: Stephen M Smith
• 金额: $ 6.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173028
• 关键词: Address; Africa; African; Area; Cercocebus atys; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Country; Disease Outbreaks; Epidemic; Funding; Grant; HIV-2; Health Personnel; Human; Immunosuppression; Individual; Institution; Lead; Population; Research; Research Personnel; Resources; SIV; Sierra Leone; Source; United States National Institutes of Health; Work; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 2 (HIV-2) emerged following cross-species transmission of SIV from sooty mangabeys to humans several decades ago in West Africa. The epidemic groups of HIV-2 are HIV-2 Group A and Group B. These 2 groups have been established in the human population for at least 50 years. However, it is likely that new divergent strains of SIV can infect humans and lead to new outbreaks. We isolated characterized a new HIV-2 group F, HIV2-NWK08F, in 2008 from an immunodeficient Sierra Leonian who immigrated to the USA in 2007. Health care providers in Sierra Leone and elsewhere need to be alerted that a strain of HIV-2, which is not detected by PCR for epidemic HIV-2 strains, exists and can lead to immunosuppression. This is the first HIV-2 to emerge from an Anglophone African country. The question remains as to whether HIV-2 NWK08F is emerging in Sierra Leone. To address this question, collaborations were established in Sierra Leone and a preliminary trip made to Kerema and Kambala to lay ground work for a serosurvery of 1000 individuals in the area where HIV-2 NWK08F emerged.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构为 研究中心，而研究中心不一定是研究者所在的机构。 人类免疫缺陷病毒2型（HIV-2）是几十年前在西非从非洲白眉猴跨物种传播SIV给人类后出现的。 HIV-2的流行组为HIV-2 A组和HIV-2 B组。 这两个群体已经在人群中建立了至少50年。 然而，新的SIV不同毒株可能会感染人类并导致新的疫情。 2008年，我们从一名2007年移民到美国的免疫缺陷塞拉利昂人中分离出一种新的HIV-2 F组，HIV 2-NWK 08 F。塞拉利昂和其他地方的卫生保健提供者需要警惕存在一种HIV-2毒株，这种毒株不能通过PCR检测到流行的HIV-2毒株，并可能导致免疫抑制。 这是第一个来自非洲英语国家的HIV-2。 目前的问题是，塞拉利昂是否出现了HIV-2 NWK 08 F。 为解决这一问题，在塞拉利昂建立了合作关系，并对凯雷马和坎巴拉进行了初步访问，为在出现HIV-2 NWK 08 F的地区对1 000人进行血清调查奠定基础。