Increasing Sleep Duration: A Novel Approach to Weight Control

增加睡眠时间：控制体重的新方法

• 批准号: 7941883
• 负责人: Rena R Wing
• 金额: $ 95.21万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941883
• 关键词: Acute; Adherence; Adult; Affect; Age; Area; Basic Science; Behavior; Behavior Therapy; Behavioral; Behavioral Genetics; Body Weight; Body Weight decreased; Circadian Rhythms; Clinical; Clinical Trials; Comorbidity; Diabetes Mellitus; Doctor of Philosophy; Eating; Eating Behavior; Endocrinology; Ensure; Epidemic; Epidemiologic Studies; Exercise; Faculty; Feasibility Studies; Functional Magnetic Resonance Imaging; Future; Health; Hour; Hypertension; Impulsivity; Individual; Intervention; Intervention Studies; Laboratory Study; Life; Link; Maintenance; Measurement; Measures; Moods; Neuropsychological Tests; Obesity; Overweight; Patients; Phase; Physical activity; Physiological; Population; Principal Investigator; Procedures; Protocols documentation; Randomized; Recommendation; Relative (related person); Research; Research Personnel; Risk-Taking; Series; Sleep; Sleep Apnea Syndromes; Sleeplessness; Target Populations; Testing; Translating; Weight; Weight maintenance regimen; Wing; abstracting; cognitive change; cognitive function; executive function; mortality; multidisciplinary; neuropsychological; novel; novel strategies; primary outcome; programs; psychologic; randomized trial; therapy development; trial comparing; weight loss intervention; young adult

DESCRIPTION (provided by applicant): Simultaneous with the epidemic of obesity, there has been an epidemic of short sleep duration. Epidemiological studies have documented a link between short sleep duration and both obesity and obesity- related health problems including hypertension, diabetes, and mortality and basic laboratory studies have identified physiological mechanisms that may explain this association. However, to date, there have been no intervention studies examining the impact of changes in sleep duration on changes in body weight. The Center for Behavioral Intervention Development (CBID) proposed in this application seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. We propose a programmatic series of studies to develop a sleep + weight loss intervention. The target population for our studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BIVII 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. We will also examine the effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations. The proposed CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior, and physiological changes associated with sleep and weight. RELEVANCE: Both obesity and short sleep duration are major health problems, with a variety of negative consequences. Given that short sleep may contribute to the problem of obesity, this proposal seeks to develop an intervention to increase sleep duration and to determine whether increasing sleep alone, or in combination with a weight loss program, can have positive effects on eating, exercise, and ultimately weight control. (End of Abstract)

描述（由申请人提供）： 在肥胖症流行的同时，睡眠时间短也在流行。流行病学研究已经证明了睡眠时间短与肥胖和肥胖相关的健康问题（包括高血压、糖尿病和死亡率）之间的联系，并且基础实验室研究已经确定了可以解释这种联系的生理机制。然而，到目前为止，还没有干预研究检查睡眠时间的变化对体重变化的影响。在本申请中提出的行为干预发展中心（CBID）寻求将关于睡眠持续时间的基础科学转化为减少肥胖和肥胖相关的共病的新型干预。我们提出了一系列程序性研究，以开发睡眠+减肥干预。我们研究的目标人群是年轻人（25 - 45岁），他们的睡眠时间和肥胖之间的联系似乎最强，超重或肥胖（BIVII 25 - 40），并且目前每晚睡眠时间少于6.5小时。这一系列的研究将被用来检查睡眠时间的增加单独和结合减肥计划对饮食和运动行为（客观测量）的影响，并最终对体重的影响。我们还将研究增加睡眠时间对生理，心理和认知变化的影响，这些变化可能与饮食和活动的变化以及遵守体重控制建议有关。拟议的CBID创建了一个新的跨学科团队，包括行为体重控制，睡眠的基本和临床方面，认知功能的fMRI和神经心理学评估，饮食和运动行为以及与睡眠和体重相关的生理变化等领域的研究人员。相关性：肥胖和睡眠时间短都是主要的健康问题，会带来各种负面后果。鉴于睡眠不足可能导致肥胖问题，该提案旨在制定一项干预措施，以增加睡眠时间，并确定单独增加睡眠或与减肥计划相结合是否可以对饮食，运动和最终控制体重产生积极影响。(End摘要）