Prevention of Weight Gain in Young Adults

预防年轻人体重增加

• 批准号: 8296628
• 负责人: Rena R Wing
• 金额: $ 105.14万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-18 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8296628
• 关键词: Accountability; Adherence; Adult; African American; Age; Age-Years; Americas; Area; Behavior; Behavioral; Blood Pressure; Body Weight; Body Weight Changes; Body Weight decreased; Cardiovascular system; Clinical; Clinical Trials; Collaborations; Control Groups; Data; Data Coordinating Center; Development; Diet; Eating; Eating Behavior; Educational process of instructing; Environmental Risk Factor; Epidemic; Equipment and supply inventories; Ethnic Origin; Exercise; Frequencies; Goals; Grant; Health; Hospitals; Individual; Informal Social Control; Intake; Intervention; Lead; Life; Life Style; Link; Lipids; Maintenance; Measures; Mediator of activation protein; Menopause; Mental Depression; Metabolic syndrome; North Carolina; Obesity; Participant; Physical activity; Pilot Projects; Population Study; Prevalence; Prevention program; Preventive Intervention; Process Measure; Psychological reinforcement; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Recommendation; Recording of previous events; Recruitment Activity; Reporting; Research; Research Priority; Risk Factors; Self Efficacy; Strategic Planning; System; Testing; Text; Time; Translating; United States National Institutes of Health; Universities; University Hospitals; Weight; Weight Gain; Weight maintenance regimen; Wing; Woman; Work; abstracting; age group; aged; arm; base; behavior change; cardiovascular disorder risk; cardiovascular risk factor; clinical research site; comparative efficacy; design; experience; follow-up; forest; group intervention; high risk; improved; innovation; insulin sensitivity; intervention effect; medical schools; meetings; obesity in children; obesity prevention; preference; prevent; programs; psychologic; psychosocial; public health priorities; restraint; satisfaction; skills; therapy design; trial comparing; waist circumference; weight gain prevention; young adult

DESCRIPTION (provided by applicant): Young adults, age 20-35, experience the greatest rate of weight gain, averaging 1 to 2 pounds per year. This weight gain is associated with a worsening in cardiovascular risk factors and an increase in the prevalence of metabolic syndrome. Given the difficulties in producing sustained weight loss later in life, preventing weight gain from occurring during young adulthood is critical to curbing the obesity epidemic. This project involves two linked R01 applications--a Clinical Coordinating Center application submitted by Dr. Rena Wing, The Miriam Hospital, and a Data Coordinating Center, submitted by Dr. Mark Espeland, Wake Forest University School of Medicine. The purpose of the project is to test two interventions to prevent weight gain in young adults. Both interventions are based on a self-regulation approach that we have shown can help prevent weight regain in recent weight losers. Key aspects of this self-regulation include daily self-weighing, use of the information from the scale to know when adjustments in eating and activity are needed, behavioral skills to modify these behaviors, and small reinforcements for successful prevention of weight gain. One self-regulation intervention is focused on making small consistent changes in eating and exercise behavior to prevent weight gain; the other emphasizes periodic larger changes in eating and exercise behavior that result in small weight losses. These interventions will be compared to each other and to a control condition in a 3-armed randomized controlled clinical trial. The study will involve 600 adults (300 at the Miriam Hospital clinical site and 300 at the University of North Carolina clinical site), aged 18-35 with a BMI of 23-30, who are randomly assigned to 1) control; 2) self-regulation intervention with small behavior changes or 3) self-regulation with large behavior changes. Participants will be recruited over 18 months and will be followed from randomization until the end of the grant, resulting in 24-48 months of follow-up (mean=3 years). The primary hypothesis is that the magnitude of weight gain across an average planned follow-up of 3 years will differ among the three groups (a priori hypothesis is that weight gain will be greatest in control, intermediate in small changes, and least in the large change condition). Secondary hypotheses will compare the three groups on the proportion gaining weight (defined as > 1lb over baseline), changes in cardiovascular risk factors, and changes in the process measures (such as diet, physical activity, and dietary restraint). This project focuses on weight gain in young adults-a critical time for the prevention of obesity-and tests innovative approaches based on self-regulation of body eight. This approach shows promise for reducing weight gain and thereby improving long-term cardiovascular health. (End of Abstract)

描述（由申请人提供）： 20-35岁的年轻人体重增加速度最快，平均每年1至2磅。这种体重增加与心血管危险因素的恶化和代谢综合征患病率的增加有关。考虑到在以后的生活中产生持续的体重减轻的困难，防止体重增加发生在年轻的成年人是至关重要的，以遏制肥胖症的流行。该项目涉及两个相关的R 01申请--由Miriam医院的雷纳翼博士提交的临床协调中心申请和由维克森林大学医学院的Mark Espeland博士提交的数据协调中心申请。该项目的目的是测试两种预防年轻人体重增加的干预措施。这两种干预措施都是基于自我调节的方法，我们已经证明这种方法可以帮助防止最近减肥者的体重反弹。这种自我调节的关键方面包括每日自我称重，使用秤上的信息来了解何时需要调整饮食和活动，改变这些行为的行为技能，以及成功预防体重增加的小强化。一种自我调节干预措施侧重于在饮食和运动行为方面进行小的一致性改变，以防止体重增加;另一种强调饮食和运动行为的周期性较大变化，导致体重小幅下降。这些干预措施将在3组随机对照临床试验中相互比较并与对照条件进行比较。该研究将涉及600名年龄为18-35岁、BMI为23-30的成年人（300名在Miriam医院临床中心，300名在北卡罗来纳州大学临床中心），将其随机分配至1）对照组; 2）自我调节干预组（行为变化较小）或3）自我调节组（行为变化较大）。参与者将在18个月内招募，并将从随机化到补助金结束进行随访，随访时间为24-48个月（平均=3年）。主要假设是，在平均3年计划随访期间，三组之间的体重增加幅度将不同（先验假设是，对照组体重增加最大，小变化组体重增加居中，大变化组体重增加最小）。次要假设将比较三组体重增加的比例（定义为超过基线1磅），心血管危险因素的变化以及过程测量（如饮食，体力活动和饮食限制）的变化。这个项目的重点是年轻人的体重增加这是预防肥胖的关键时期并测试了基于第八体自我调节的创新方法。这种方法有望减少体重增加，从而改善长期心血管健康。 (End摘要）