Identification of human gene polymorphisms related to Vibrio cholerae infection
人类霍乱弧菌感染相关基因多态性鉴定
基本信息
- 批准号:7556813
- 负责人:
- 金额:$ 13.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-15 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:BangladeshBostonCholeraCommunicable DiseasesDataDevelopmentDiseaseEnteralFacultyFundingFutureGeneral HospitalsGenesGenetic PolymorphismGenetic ResearchHealthHumanHuman GeneticsHuman IdentificationsInfectionInternationalK-Series Research Career ProgramsLaboratoriesMassachusettsMentorsMentorshipNatural SelectionsPopulationPredispositionPrincipal InvestigatorResearchResearch EthicsResearch PersonnelScienceScientistTrainingTraining ProgramsUnited States National Institutes of HealthVariantVibrio choleraeacquired immunitycareergenome wide association studyinternational centerprograms
项目摘要
DESCRIPTION (provided by applicant): This application details a three-year renewal of a K01 International Research Scientist Career Development Award focused on identifying human gene polymorphisms related to Vibrio cholerae infection. The program will be conducted under the collaborative mentorship of Dr. Stephen B. Calderwood, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts and Dr. Firdausi Qadri, Laboratory Sciences Division, International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh. The candidate is trained in Infectious Diseases and has a documented commitment to an independent research career in the field of international health. The training program will include courses in human genetics and research ethics. The research component will focus on three specific aims: (1) to characterize the association between susceptibility to Vibrio cholerae infection and variants in candidate human genes related to innate and acquired immunity; (2) to determine the functional consequences of polymorphisms in genes that are found to be associated with susceptibility to Vibrio cholerae infection; and (3) to identify candidate loci for natural selection in the Bangladeshi population. The mentors and supporting faculty will assist with the progress of the applicant's research. The program will allow the candidate to further develop as an independent biomedical researcher focused on global health challenges. Furthermore, data generated with the support of this program will enable the candidate to apply for NIH funding for future studies of human genetic factors associated with cholera and other enteric infections.
描述(由申请人提供):本申请详细介绍了 K01 国际研究科学家职业发展奖的三年续展,重点是识别与霍乱弧菌感染相关的人类基因多态性。该计划将在马萨诸塞州波士顿马萨诸塞州总医院传染病科 Stephen B. Calderwood 博士和孟加拉国达卡国际腹泻病研究中心实验室科学部 Firdausi Qadri 博士的合作指导下进行。候选人接受过传染病方面的培训,并有文件记录致力于国际卫生领域的独立研究事业。培训计划将包括人类遗传学和研究伦理学课程。该研究部分将重点关注三个具体目标:(1)表征霍乱弧菌感染的易感性与先天性和获得性免疫相关的候选人类基因变异之间的关联; (2) 确定与霍乱弧菌感染易感性相关的基因多态性的功能后果; (3) 确定孟加拉国人口中自然选择的候选基因座。导师和支持教师将协助申请人的研究进展。该计划将使候选人进一步发展成为专注于全球健康挑战的独立生物医学研究员。此外,在该计划的支持下生成的数据将使候选人能够申请美国国立卫生研究院的资助,用于未来与霍乱和其他肠道感染相关的人类遗传因素的研究。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic.
对海地和多米尼加共和国霍乱菌株进行高深度全基因组测序。
- DOI:10.1186/1471-2164-13-468
- 发表时间:2012
- 期刊:
- 影响因子:4.4
- 作者:Sealfon,Rachel;Gire,Stephen;Ellis,Crystal;Calderwood,Stephen;Qadri,Firdausi;Hensley,Lisa;Kellis,Manolis;Ryan,EdwardT;LaRocque,ReginaC;Harris,JasonB;Sabeti,PardisC
- 通讯作者:Sabeti,PardisC
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REGINA C LAROCQUE其他文献
REGINA C LAROCQUE的其他文献
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{{ truncateString('REGINA C LAROCQUE', 18)}}的其他基金
Global TravEpiNet (GTEN): U.S. Travelers' Health Research, Surveillance, Communication and Outreach Network Supplement
Global TravEpiNet (GTEN):美国旅行者健康研究、监测、通信和外展网络补充
- 批准号:
10674592 - 财政年份:2021
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): U.S. Travelers? Health Research, Surveillance, Communication and Outreach Network
Global TravEpiNet (GTEN):美国旅行者?
- 批准号:
10701047 - 财政年份:2021
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): U.S. Travelers? Health Research, Surveillance, Communication and Outreach Network
Global TravEpiNet (GTEN):美国旅行者?
- 批准号:
10318495 - 财政年份:2021
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): the Heading Home Healthy Program and Global Travelers' Health National Research Center Consortium, Guidance and Outreach Programs
Global TravEpiNet (GTEN):回家健康计划和全球旅行者健康国家研究中心联盟、指导和外展计划
- 批准号:
9763383 - 财政年份:2016
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): the Heading Home Healthy Program and Global Travelers' Health National Research Center Consortium, Guidance and Outreach Programs
Global TravEpiNet (GTEN):回家健康计划和全球旅行者健康国家研究中心联盟、指导和外展计划
- 批准号:
9211747 - 财政年份:2016
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): the Heading Home Healthy Program and Global Travelers' Health National Research Center Consortium, Guidance and Outreach Programs
Global TravEpiNet (GTEN):回家健康计划和全球旅行者健康国家研究中心联盟、指导和外展计划
- 批准号:
10160720 - 财政年份:2016
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet (GTEN): the Heading Home Healthy Program and Global Travelers' Health National Research Center Consortium, Guidance and Outreach Programs
Global TravEpiNet (GTEN):回家健康计划和全球旅行者健康国家研究中心联盟、指导和外展计划
- 批准号:
10330362 - 财政年份:2016
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet: Global Travelers' Health Surveillance, Applications, and Cons
Global TravEpiNet:全球旅行者的健康监测、应用程序和缺点
- 批准号:
8912977 - 财政年份:2011
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet: Global Travelers' Health Surveillance, Applications, and Cons
Global TravEpiNet:全球旅行者的健康监测、应用程序和缺点
- 批准号:
8535149 - 财政年份:2011
- 资助金额:
$ 13.18万 - 项目类别:
Global TravEpiNet: Global Travelers' Health Surveillance, Applications, and Cons
Global TravEpiNet:全球旅行者的健康监测、应用程序和缺点
- 批准号:
8203914 - 财政年份:2011
- 资助金额:
$ 13.18万 - 项目类别:
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