Identification of human gene polymorphisms related to Vibrio cholerae infection

描述（由申请人提供）：本申请详细说明了K01国际研究科学家职业发展奖的三年续期，重点是识别与霍乱弧菌感染相关的人类基因多态性。该计划将在马萨诸塞州波士顿马萨诸塞州总医院传染病科Stephen B. Calderwood博士和孟加拉国达卡国际腹泻病研究中心实验室科学部Firdausi Qadri博士的合作指导下进行。该候选人接受过传染病方面的培训，并有文件证明致力于国际卫生领域的独立研究事业。培训项目将包括人类遗传学和研究伦理课程。该研究将集中在三个具体目标上：(1)确定对霍乱弧菌感染的易感性与与先天免疫和获得性免疫相关的候选人类基因变异之间的关系；(2)确定与霍乱弧菌感染易感性相关的基因多态性的功能后果；(3)在孟加拉国人群中确定自然选择的候选位点。导师和支持教师将协助申请人的研究进展。该计划将使候选人进一步发展成为一名专注于全球健康挑战的独立生物医学研究人员。此外，在该计划支持下生成的数据将使候选人能够申请NIH资助，用于与霍乱和其他肠道感染相关的人类遗传因素的未来研究。

DESCRIPTION (provided by applicant): This application details a three-year renewal of a K01 International Research Scientist Career Development Award focused on identifying human gene polymorphisms related to Vibrio cholerae infection. The program will be conducted under the collaborative mentorship of Dr. Stephen B. Calderwood, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts and Dr. Firdausi Qadri, Laboratory Sciences Division, International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh. The candidate is trained in Infectious Diseases and has a documented commitment to an independent research career in the field of international health. The training program will include courses in human genetics and research ethics. The research component will focus on three specific aims: (1) to characterize the association between susceptibility to Vibrio cholerae infection and variants in candidate human genes related to innate and acquired immunity; (2) to determine the functional consequences of polymorphisms in genes that are found to be associated with susceptibility to Vibrio cholerae infection; and (3) to identify candidate loci for natural selection in the Bangladeshi population. The mentors and supporting faculty will assist with the progress of the applicant's research. The program will allow the candidate to further develop as an independent biomedical researcher focused on global health challenges. Furthermore, data generated with the support of this program will enable the candidate to apply for NIH funding for future studies of human genetic factors associated with cholera and other enteric infections.