Host-pathogen interaction in Vibrio cholerae infection

描述(由申请者提供)：本申请详细说明了一个为期四年的细菌发病机制国际研究生涯发展计划。该计划将在马萨诸塞州波士顿马萨诸塞州总医院传染病科斯蒂芬·B·卡尔德伍德博士和孟加拉国达卡B：卫生与人口研究中心ICDDR实验室科学部Firdausi Qadri博士的合作指导下进行。候选人受过传染病方面的培训，并有在细菌发病机制和国际卫生领域追求独立研究生涯的长期目标。培训计划将包括免疫学、遗传学和研究伦理方面的课程。研究部分将侧重于霍乱弧菌感染中宿主与病原体的相互作用。本研究的目标有三个：(1)利用高通量基因芯片技术鉴定霍乱弧菌的毒力因子；(2)鉴定霍乱弧菌保护性免疫应答中重要的免疫优势蛋白；(3)研究影响霍乱弧菌易感性的宿主遗传因素。导师和咨询委员会将监督申请者的进展和研究。该计划将使候选人获得技能、知识和经验，成为一名专注于全球健康挑战的独立生物医学研究人员。

DESCRIPTION (provided by applicant): This application details a four-year international research career development program in bacterial pathogenesis. The program will be conducted under the collaborative mentorship of Dr. Stephen B. Calderwood, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts and Dr. Firdausi Qadri, Laboratory Sciences Division, ICDDR,B: Centre for Health and Population Research, Dhaka, Bangladesh. The candidate is trained in Infectious Diseases and has the long-term goal of pursuing an independent research career in the field of bacterial pathogenesis and international health. The training program will include courses in immunology, genetics and research ethics. The research component will focus on host-pathogen interactions in Vibrio cholerae infection. Three specific aims will be addressed: (1) to use high-throughput gene microarray techniques to identify virulence factors of V. cholerae; (2) to characterize immunodominant proteins important in the protective immune response to V. cholerae; and (3) to study host genetic factors which influence susceptibility to V. cholerae. The mentors and an advisory committee will oversee the applicant's progress and research. The program will allow the candidate to obtain the skills, knowledge and experience to become an independent biomedical researcher focused on global health challenges.