NIGMS Biomedical Research Core Center in Immunology and Imaging

描述（由申请人提供）：新墨西哥大学病理学系提议在免疫学和影像学方面建立NIGMS生物医学研究核心中心（BRCC），该中心将招聘和指导两名杰出的博士，医学博士或医学博士/博士终身教职研究人员，达到助理教授水平。新成员将加入一个新的医师/科学家主任，一个强大的临床使命和一个成功的研究团队，强调创新技术和临床转化。病理学研究是新近通过奖励（积极或预期）的三个主要跨学科NIH拨款，两个来自NIGMS和一个来自NIH共同基金。新墨西哥细胞信号时空建模中心（NIH P50GM085273; 2009-2014），由J. Oliver（病理学）领导，专注于肥大细胞、嗜碱性细胞和其他免疫细胞信号通路的动态高分辨率成像和计算建模。新墨西哥分子发现中心（NIH U54MH084690; 2008-2013），由L. Sklar（病理学）领导，使用高通量流式细胞术和化学信息学来发现和开发针对免疫和癌细胞靶点的特异性药物。新墨西哥州学术科学教育和研究培训计划（NIH K12GM088021; 2009-2014），由a . Wandinger-Ness（病理学）领导，为少数民族（和其他）博士后在研究和教学方面的成功做好准备，作为下一代学术教师多样化的一种手段。病理学系在2008年中期承诺招募一到两名年轻的教师，寻求在人类免疫学方面建立研究事业，以补充新生的研究中心。研究领域有目的地很广（“抗病原体免疫、针对癌症、自身免疫性疾病、炎症性疾病或先天免疫系统的免疫监测”），职位描述指定申请人“对创新成像技术表现出兴趣/专业知识”。虽然招聘得到了院系和人力资源部的全面批准，但2008年12月实施的全校范围内的招聘冻结阻止了招聘。随着新资金的注入，病理学系更有能力招募和指导两名优秀的年轻科学家，他们在免疫学和影像学方面的跨学科研究将补充病理主导的研究中心，他们的学术生涯发展将受益于病理主导的培训计划。卫生科学副主席P. Roth已批准恢复终身职位的搜寻工作，但须由国家卫生管理系统提供资金，并将保证为新聘人员再提供两年的部分薪金支助。BRCC实验室已经在病理学研究空间中确定了适合两名新员工的实验室，该部门将支持额外的工资、设置和翻新费用。专门的BRCC办公空间与实验室相连。BRCC免疫学和影像学的教职员工将建立外部资助的跨学科研究项目，这些项目将在P30资助的两年之后的几十年里蓬勃发展。

DESCRIPTION (provided by applicant): The Department of Pathology at the University of New Mexico proposes a NIGMS Biomedical Research Core Center (BRCC) in Immunology and Imaging that will recruit and mentor two outstanding PhD, MD or MD/PhD tenure track research faculty at the Assistant Professor level. The recruits will join a department with a new physician/scientist chair, a strong clinical mission and an accomplished research faculty that emphasizes innovative technologies and clinical translation. Pathology research is newly invigorated through the award (active or anticipated) of three major interdisciplinary NIH grants, two from NIGMS and one from the NIH Common Fund. The New Mexico Center for Spatiotemporal Modeling of Cell Signaling (NIH P50GM085273; 2009-2014), led by J. Oliver (Pathology), focuses on dynamic high resolution imaging and computational modeling of signaling pathways in mast cells, basophils and other immune cells. The New Mexico Center for Molecular Discovery (NIH U54MH084690; 2008-2013), led by L. Sklar (Pathology), uses high throughput flow cytometry and chemiinformatics to discover and develop drugs specific for targets in immune and cancer cells. The New Mexico Academic Science Education and Research Training Program (NIH K12GM088021; 2009-2014), led by A. Wandinger-Ness (Pathology), prepares minority (and other) postdocs for success in research and teaching as a means of diversifying the next generation of academic faculty. The Department of Pathology committed in mid-2008 to recruit one or two junior faculty seeking to establish research careers in human immunology complementary to the nascent research centers. The research area was purposely broad ("anti-pathogen immunity, immune surveillance against cancer, autoimmune diseases, inflammatory illnesses or the innate immune system") and the job description specified applicants "with demonstrated interest/expertise in innovative imaging techniques." Although recruiting was fully approved by the department and by HR, a University-wide hiring freeze imposed in December 2008 blocked the search. With the infusion of new funding, the Department of Pathology is even more strongly positioned to recruit and mentor two superb young scientists whose interdisciplinary research in immunology and imaging would complement the Pathology-led research centers and whose academic career development would benefit from the Pathology-led training program. Vice-President for Health Sciences, P. Roth, has approved the resumption of the tenure-track search, subject to NIGMS funding, and will guarantee a further two years of partial salary support for the recruits. BRCC laboratories suitable for two recruits have been identified in available Pathology research space and the department will support additional salary, setup and renovation costs. Dedicated BRCC office space is linked to the labs. Faculty recruited to the BRCC in Immunology and Imaging will establish externally-funded interdisciplinary research programs that will grow and flourish for decades beyond the two years of P30 funding.