NIGMS Biomedical Research Core Center in Immunology and Imaging

描述(由申请者提供)：新墨西哥大学病理学系建议在免疫学和成像领域建立NIGMS生物医学研究核心中心(BRCC)，该中心将招聘和指导两名杰出的博士、医学博士或医学博士/博士终身教职助理教授。这些新人将加入一个新的医生/科学家主席、强大的临床使命和一支专注于创新技术和临床翻译的有成就的研究人员的部门。病理学研究最近通过授予(正在进行的或预期的)三项NIH跨学科拨款而重新焕发活力，其中两项来自NIGMS，一项来自NIH共同基金。新墨西哥细胞信号时空建模中心(NIH P50GM085273；2009-2014)由J.Oliver(病理学)领导，专注于肥大细胞、嗜碱性粒细胞和其他免疫细胞中信号通路的动态高分辨率成像和计算建模。新墨西哥州分子发现中心(NIH U54MH084690；2008-2013)由L.Sklar(病理学)领导，使用高通量流式细胞术和化学信息学来发现和开发针对免疫和癌细胞靶标的药物。新墨西哥州学术科学教育和研究培训计划(NIH K12GM088021；2009-2014)由A.Wandinger-Ness(病理学)领导，为少数族裔(和其他)博士后在研究和教学方面的成功做准备，以此作为多元化下一代学术教师的一种手段。病理学系在2008年年中承诺招聘一到两名初级教员，寻求在人类免疫学方面建立研究生涯，与新成立的研究中心相辅相成。研究领域特意宽泛(“抗病原体免疫、对癌症、自身免疫性疾病、炎症性疾病或先天免疫系统的免疫监测”)，职位描述规定应聘者“对创新成像技术表现出兴趣/专业知识”。尽管招聘得到了教育部和人力资源部的完全批准，但2008年12月实施的全大学范围内的招聘冻结阻止了招聘。随着新资金的注入，病理学系更有能力招聘和指导两名优秀的年轻科学家，他们在免疫学和成像方面的跨学科研究将补充病理学主导的研究中心，他们的学术生涯发展将受益于病理学主导的培训计划。负责健康科学的副总裁P.Roth已批准恢复终身教职跟踪搜索，但需得到NIGMS的资助，并将保证为新招聘人员再提供两年的部分工资支持。在可用的病理学研究空间内，已经确定了适合两名新聘人员的BRCC实验室，该部门将支持额外的工资、安装和翻新费用。专门的BRCC办公空间与实验室相连。招募到BRCC免疫学和成像专业的教员将建立外部资助的跨学科研究项目，这些项目将在P30资助的两年后继续发展和繁荣数十年。

DESCRIPTION (provided by applicant): The Department of Pathology at the University of New Mexico proposes a NIGMS Biomedical Research Core Center (BRCC) in Immunology and Imaging that will recruit and mentor two outstanding PhD, MD or MD/PhD tenure track research faculty at the Assistant Professor level. The recruits will join a department with a new physician/scientist chair, a strong clinical mission and an accomplished research faculty that emphasizes innovative technologies and clinical translation. Pathology research is newly invigorated through the award (active or anticipated) of three major interdisciplinary NIH grants, two from NIGMS and one from the NIH Common Fund. The New Mexico Center for Spatiotemporal Modeling of Cell Signaling (NIH P50GM085273; 2009-2014), led by J. Oliver (Pathology), focuses on dynamic high resolution imaging and computational modeling of signaling pathways in mast cells, basophils and other immune cells. The New Mexico Center for Molecular Discovery (NIH U54MH084690; 2008-2013), led by L. Sklar (Pathology), uses high throughput flow cytometry and chemiinformatics to discover and develop drugs specific for targets in immune and cancer cells. The New Mexico Academic Science Education and Research Training Program (NIH K12GM088021; 2009-2014), led by A. Wandinger-Ness (Pathology), prepares minority (and other) postdocs for success in research and teaching as a means of diversifying the next generation of academic faculty. The Department of Pathology committed in mid-2008 to recruit one or two junior faculty seeking to establish research careers in human immunology complementary to the nascent research centers. The research area was purposely broad ("anti-pathogen immunity, immune surveillance against cancer, autoimmune diseases, inflammatory illnesses or the innate immune system") and the job description specified applicants "with demonstrated interest/expertise in innovative imaging techniques." Although recruiting was fully approved by the department and by HR, a University-wide hiring freeze imposed in December 2008 blocked the search. With the infusion of new funding, the Department of Pathology is even more strongly positioned to recruit and mentor two superb young scientists whose interdisciplinary research in immunology and imaging would complement the Pathology-led research centers and whose academic career development would benefit from the Pathology-led training program. Vice-President for Health Sciences, P. Roth, has approved the resumption of the tenure-track search, subject to NIGMS funding, and will guarantee a further two years of partial salary support for the recruits. BRCC laboratories suitable for two recruits have been identified in available Pathology research space and the department will support additional salary, setup and renovation costs. Dedicated BRCC office space is linked to the labs. Faculty recruited to the BRCC in Immunology and Imaging will establish externally-funded interdisciplinary research programs that will grow and flourish for decades beyond the two years of P30 funding.