Recruitment of New Faculty to Enhance Research in Lung Biology

招聘新教师以加强肺生物学研究

• 批准号: 7858936
• 负责人: Jacob I Sznajder
• 金额: $ 44.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7858936
• 关键词: Adult; Biology; Chronic lung disease; Cicatrix; Complement; Critical Care; Development; Disease; Evaluation; Extramural Activities; Faculty; Fostering; Funding; Goals; Healed; Injury; Interdisciplinary Study; Lung; Lung diseases; Measures; Medicine; Mentorship; Molecular Medicine; Pathway interactions; Patients; Prevention; Preventive; Process; Recruitment Activity; Research; Research Personnel; Role; Seminal; Signal Transduction; Structure; Supervision; Time; Translating; United States; Universities; Wound Healing; career; career development; healing; injury and repair; innovation; laboratory facility; lung injury; meetings; member; mortality; novel therapeutics; programs; response to injury; treatment strategy

DESCRIPTION (provided by applicant): Mortality of patients with chronic lung diseases continues to ncrease in the United States. Understanding the mechanisms of how the lung responds to injury and how this leads to abnormal lung healing is key to the development of novel therapeutic strategies to treat fibrotic diseases in the lung. The goal of our program at the Division of Pulmonary and Critical Care Medicine is to Division of Pulmonary and Critical Care Medicine of Northwestern University is to foster the career development of young investigators to focus on lung biology and to advance the understanding and treatment of pulmonary disorders. This interdisciplinary focus is reflected in the breadth of the lung disease research performed by our faculty members. Our program seeks to encourage young faculty to translate the rapid advances in molecular medicine to the bedside of patients with lung disease. To this goal, we are proposing this program to provide support for the hiring of new tenure-track faculty with a commitment to advancing their academic career; provide mentorship by senior investigators who are experts in their field; provide the laboratory facilities, foster collaborative relationships, and skilled supervision required for the advancement of independent investigators; and create an administrative structure that facilitates the new faculty's acquisition of independent extramural funding. To further the research in lung biology, we propose the recruitment of Dr. Lam to our Division. Dr. Lam is a new investigator who is collaborating with several investigators in the Division of Pulmonary and Critical Care Medicine of Northwestern University and providing some ofthe seminal research in understanding the role of the canonical Wnt/p-catenin pathway in adult lung response to injury and repair. The Division of Pulmonary and Critical Care Medicine of Northwestern University is a center for innovative research into the mechanisms of lung injury, the addition of Dr. Lam and her research on the role p-catenin signaling in abnormal wound repair will not only complement but also elevate the scientific capacity of the Division. Understanding the mechanisms by which p-catenin signaling effects fibroproliferative diseases in the lung will have significant impact not only upon the understanding of fundamentals lung biology but also upon strategies for treatment and prevention of these devastating diseases. Lung diseases are on the rise in the United States and around the world. Understanding how the lung responds to injury and how aberrant healing leads to lung scarring is vital in order to develop preventive and treatment measures. To this goal, new investigators need to be recruited to develop collaborative, multidisciplinary research that will facitlitate rapid advances in molecular medicine to the bedside.

描述（由申请人提供）：在美国，慢性肺部疾病患者的死亡率继续减轻。了解肺如何应对损伤的机制以及这如何导致异常的肺部愈合是发展新型治疗策略以治疗肺中纤维化疾病的关键。我们在肺部和重症监护医学部门计划的目标是西北大学肺和重症监护医学的划分是促进年轻研究人员的职业发展，以专注于肺部生物学，并促进对肺部疾病的理解和治疗。这种跨学科的重点反映在我们教职员工进行的肺部疾病研究的广度上。我们的计划旨在鼓励年轻教师将分子医学的快速进步转化为肺部疾病患者的床边。为了实现这一目标，我们建议该计划为雇用新的终身教师提供支持，并致力于推进他们的学术生涯；提供领域专家的高级调查员的指导；提供实验室设施，促进协作关系以及独立研究人员的发展所需的熟练监督；并建立一种行政结构，以促进新教师收购独立的壁外资金。为了进一步研究肺部生物学的研究，我们建议将Lam博士招募到我们的部门。 Lam博士是一名新的研究者，他正在与西北大学肺和重症监护医学的几位研究人员合作，并提供了一些开创性研究，以理解成人肺对损伤和修复反应的规范WNT/P-catenin途径的作用。西北大学的肺和重症监护医学部是针对肺损伤机制的创新研究中心，LAM博士的增加以及她对P-catenin信号在异常伤口修复中的作用的研究不仅会补充，而且还可以提高该部门的科学能力。了解肺中P蛋白信号效应纤维增生性疾病的机制不仅会对理解基本面肺部生物学的理解产生重大影响，而且还对治疗和预防这些破坏性疾病的策略。 在美国和世界各地，肺部疾病正在上升。了解肺对损伤的反应以及异常愈合如何导致肺部疤痕至关重要，这对于制定预防和治疗措施至关重要。为了实现这一目标，需要招募新的研究人员来开发合作，多学科研究，这将使分子医学在床边的快速发展。