Recruitment of New Faculty to Enhance Research in Lung Biology

招聘新教师以加强肺生物学研究

• 批准号: 7936173
• 负责人: Jacob I Sznajder
• 金额: $ 44.62万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936173
• 关键词: Recruitment; New; Faculty; Enhance; Research

DESCRIPTION (provided by applicant): Mortality of patients with chronic lung diseases continues to ncrease in the United States. Understanding the mechanisms of how the lung responds to injury and how this leads to abnormal lung healing is key to the development of novel therapeutic strategies to treat fibrotic diseases in the lung. The goal of our program at the Division of Pulmonary and Critical Care Medicine is to Division of Pulmonary and Critical Care Medicine of Northwestern University is to foster the career development of young investigators to focus on lung biology and to advance the understanding and treatment of pulmonary disorders. This interdisciplinary focus is reflected in the breadth of the lung disease research performed by our faculty members. Our program seeks to encourage young faculty to translate the rapid advances in molecular medicine to the bedside of patients with lung disease. To this goal, we are proposing this program to provide support for the hiring of new tenure-track faculty with a commitment to advancing their academic career; provide mentorship by senior investigators who are experts in their field; provide the laboratory facilities, foster collaborative relationships, and skilled supervision required for the advancement of independent investigators; and create an administrative structure that facilitates the new faculty's acquisition of independent extramural funding. To further the research in lung biology, we propose the recruitment of Dr. Lam to our Division. Dr. Lam is a new investigator who is collaborating with several investigators in the Division of Pulmonary and Critical Care Medicine of Northwestern University and providing some ofthe seminal research in understanding the role of the canonical Wnt/p-catenin pathway in adult lung response to injury and repair. The Division of Pulmonary and Critical Care Medicine of Northwestern University is a center for innovative research into the mechanisms of lung injury, the addition of Dr. Lam and her research on the role p-catenin signaling in abnormal wound repair will not only complement but also elevate the scientific capacity of the Division. Understanding the mechanisms by which p-catenin signaling effects fibroproliferative diseases in the lung will have significant impact not only upon the understanding of fundamentals lung biology but also upon strategies for treatment and prevention of these devastating diseases. Lung diseases are on the rise in the United States and around the world. Understanding how the lung responds to injury and how aberrant healing leads to lung scarring is vital in order to develop preventive and treatment measures. To this goal, new investigators need to be recruited to develop collaborative, multidisciplinary research that will facitlitate rapid advances in molecular medicine to the bedside.

描述（由申请人提供）：在美国，慢性肺病患者的死亡率持续上升。了解肺如何对损伤做出反应以及这如何导致异常肺愈合的机制是开发治疗肺纤维化疾病的新治疗策略的关键。我们在肺和重症监护医学部的计划的目标是西北大学肺和重症监护医学部是促进年轻研究人员的职业发展，专注于肺生物学，并推进肺部疾病的理解和治疗。这种跨学科的重点反映在我们的教师进行的肺部疾病研究的广度。我们的计划旨在鼓励年轻的教师将分子医学的快速进步转化为肺部疾病患者的床边。为了实现这一目标，我们提出了这个计划，以提供新的终身教职员工的聘用与承诺，以促进他们的学术生涯的支持;由谁是在他们的领域的专家高级研究员提供指导;提供实验室设施，促进合作关系，并为独立调查员的进步所需的熟练监督;并建立一个行政结构，以促进新的教师的独立校外资金的收购。为进一步发展肺部生物学的研究，我们建议聘请林博士加入本科。Lam博士是一位新的研究者，他正在与西北大学肺部和重症监护医学部的几位研究者合作，并在了解经典Wnt/β-连环蛋白通路在成人肺损伤和修复反应中的作用方面提供了一些开创性的研究。西北大学肺与重症监护医学部是肺损伤机制的创新研究中心，Lam博士的加入及其对异常伤口修复中β-连环蛋白信号作用的研究不仅将补充而且还将提升该部门的科学能力。了解β-连环蛋白信号传导影响肺纤维增生性疾病的机制不仅对了解肺生物学基础，而且对治疗和预防这些毁灭性疾病的策略具有重大影响。 肺部疾病在美国和世界各地都在上升。了解肺如何对损伤做出反应以及异常愈合如何导致肺瘢痕形成对于制定预防和治疗措施至关重要。为了实现这一目标，需要招募新的研究人员来开展合作性的多学科研究，以促进分子医学在临床上的快速发展。