Cincinnati Neuro-Oncology Research Core

描述（由申请人提供）：神经系统肿瘤是儿科人群中第二常见的肿瘤类型。与最常见的癌症（白血病）相比，在改善一些神经系统肿瘤的治疗效果方面已经取得了进展，但许多神经系统肿瘤仍然难以或不可能有效治疗。通过新疗法的发展，有机会极大地改善儿童神经系统癌症的预后。我们的假设是，基于发育生物学研究个体神经系统肿瘤类型的互动程序将识别分子过程中的关键差异和相似性，并扩展新疗法的适用性。动物模型和神经干细胞/祖细胞模型系统现在被用于研究神经系统癌症和神经系统新疗法的临床前开发

DESCRIPTION (Provided by the applicant): Tumors of the nervous system are the second most common types of neoplasm in the pediatric population. In contrast to the most common cancer (leukemia), strides have been made in improving outcomes for some nervous system tumors but many remain difficult or impossible to treat effectively. There is opportunity to dramatically improve outcome for nervous system cancer in children through development of new therapies. It is our hypothesis that interactive programs based in developmental biology studying individual nervous system tumor types will identify critical differences and similarities in molecular processes and extend the applicability of new therapies. Animal models and neural stem/progenitor cell models systems are now being used to study nervous system cancers and for preclinical development of novel therapies for nervous system tumors. Whole genome approaches are adding insight into developmental regulation and carcinogenesis. The goal of this proposal is to contribute to development of a multi-disciplinary, world-class Neuro-Oncology focus group within the Cincinnati Children's Hospital aimed at attacking the problem of neural tumors. Taking advantage of our institutional strengths in developmental biology and informatics, this will be accomplished by recruitment of 2 new Tenure Track faculty members. One is a developmental biologist with interest in the hippo signaling pathway and the other a neural tumor focused bioinformatician.