Cincinnati Neuro-Oncology Research Core

描述（由申请方提供）：神经系统肿瘤是儿科人群中第二常见的肿瘤类型。与最常见的癌症（白血病）相比，一些神经系统肿瘤在改善预后方面取得了长足的进步，但许多肿瘤仍然难以或不可能有效治疗。有机会通过开发新的治疗方法来显着改善儿童神经系统癌症的结果。我们的假设是，基于发育生物学的交互式程序研究个体神经系统肿瘤类型将识别分子过程中的关键差异和相似性，并扩展新疗法的适用性。动物模型和神经干/祖细胞模型系统目前正被用于研究神经系统癌症和用于神经系统新疗法的临床前开发 肿瘤的全基因组方法正在增加对发育调控的洞察力， 致癌作用该提案的目标是促进辛辛那提儿童医院内多学科、世界级神经肿瘤焦点小组的发展，旨在解决神经肿瘤问题。利用我们在发育生物学和信息学方面的机构优势，这将通过招聘2名新的终身教职员工来完成。一位是对河马信号通路感兴趣的发育生物学家，另一位是专注于神经肿瘤的生物信息学家。

DESCRIPTION (Provided by the applicant): Tumors of the nervous system are the second most common types of neoplasm in the pediatric population. In contrast to the most common cancer (leukemia), strides have been made in improving outcomes for some nervous system tumors but many remain difficult or impossible to treat effectively. There is opportunity to dramatically improve outcome for nervous system cancer in children through development of new therapies. It is our hypothesis that interactive programs based in developmental biology studying individual nervous system tumor types will identify critical differences and similarities in molecular processes and extend the applicability of new therapies. Animal models and neural stem/progenitor cell models systems are now being used to study nervous system cancers and for preclinical development of novel therapies for nervous system tumors. Whole genome approaches are adding insight into developmental regulation and carcinogenesis. The goal of this proposal is to contribute to development of a multi-disciplinary, world-class Neuro-Oncology focus group within the Cincinnati Children's Hospital aimed at attacking the problem of neural tumors. Taking advantage of our institutional strengths in developmental biology and informatics, this will be accomplished by recruitment of 2 new Tenure Track faculty members. One is a developmental biologist with interest in the hippo signaling pathway and the other a neural tumor focused bioinformatician.