2011 Neurofibromatosis (NF) Conference

描述（由申请人提供）：自1985年以来，儿童肿瘤基金会（CTF）每年组织一次神经纤维瘤病（NF）会议。NF会议起源于一个名为“NF联盟”的小组的小型研讨会式聚会，该小组致力于克隆神经纤维瘤病的潜在基因，NF会议已发展成为来自世界各地的300名NF研究人员和临床医生的聚会。这次会议被公认为是国际NF研究人员和医生的首要年度聚会。这一增长的主要贡献者是近年来在NF研究方面取得的重大进展，特别是最近在临床试验和药物治疗开发方面取得的进展。此外，最先进的基因组方法已经确定NF基因的突变是许多类型散发性癌症的诱因，包括河马和Ras级联在内的信号通路与NF有关，现在人们认识到Ras通路上的基因突变导致一系列疾病，包括NF1，称为“Rasopathies”。传统上是研究信息交流和建立共识的论坛，近年来，NF会议也成为报告神经纤维瘤病临床前治疗管道和扩大神经纤维瘤病临床试验领域的主要国际论坛。

DESCRIPTION (provided by applicant): The Neurofibromatosis (NF) Conference has been organized by the Children's Tumor Foundation (CTF) annually since 1985. With its roots in a small workshop-style gathering of a group called the 'NF Consortium' dedicated to cloning the genes underlying the Neurofibromatoses, the NF Conference has grown to a gathering of three hundred NF researchers and clinicians from around the world. This meeting is recognized as the premier annual gathering of international NF researchers and physicians. Major contributors to this growth are the significant advances made in NF research in recent years and, particularly, recent advances into clinical trials and drug therapy development. In addition, state-of-the-art genomic approaches have identified mutations in the NF genes as contributors to numerous types of sporadic cancers, signaling pathways including the Hippo and Ras cascades are implicated in NF, and it is now recognized that mutations in genes along the Ras pathway result in a set of disorders, including NF1, called the "Rasopathies". Traditionally a forum for research information exchange and consensus building, in recent years the NF Conference is also the principal international forum for reporting on the neurofibromatosis preclinical therapeutic pipeline and the expanding arena of neurofibromatosis clinical trials.