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2011 Neurofibromatosis (NF) Conference

2011年神经纤维瘤病（NF）会议

基本信息

批准号：
8130153
负责人：
NANCY RATNER
金额：
$ 4万
依托单位：
CHILDREN'S TUMOR FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-15 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8130153
关键词：
Address Affect American Area Avastin Award BAY 54-9085 Basic Science Benign Biotechnology Birth Blindness Books Candidate Disease Gene Cells Cellular biology Child Child Support Clinic Clinical Clinical Sciences Clinical Trials Collaborations Communication Communities Congenital Heart Defects Consensus Continuing Education Defect Disease Education Educational workshop Ensure Family history of Fostering Foundations Funding Gene Mutation Genes Genetic Genomics Goals Grant Growth Health Hereditary Disease Hour Industry International Journals Learning Disabilities Link Lovastatin Malignant - descriptor Malignant Neoplasms Medical Genetics Medical Research Mind Molecular Molecular Biology Morbidity - disease rate Mutation Nervous system structure Neurofibromatoses Neurofibromatosis 2 Neurofibromin 2 Neurosciences Newsletter Nurses Operative Surgical Procedures Pain Pathway interactions Persons Pharmaceutical Preparations Pharmacologic Substance Pharmacotherapy Phase Phase II Clinical Trials Physicians Plant Roots Play Plexiform Neurofibroma Preclinical Drug Evaluation Professional counselor Publications Publishing Recording of previous events Reporting Request for Applications Research Research Personnel Resort Role SMARCB1 gene Schwannomatosis Scientist Secure Seeds Signal Pathway Signal Transduction Sirolimus Site Snow Staging Summary Reports Syndrome Therapeutic Time Translational Research Vertebral column Work Wyoming abstracting anticancer research bench to bedside bone cancer cell deafness design drug candidate drug discovery gene cloning lapatinib lectures meetings mortality nervous system disorder pilot trial posters pre-clinical programs symposium therapy development tumor tumor growth web site working group

项目摘要

DESCRIPTION (provided by applicant): The Neurofibromatosis (NF) Conference has been organized by the Children's Tumor Foundation (CTF) annually since 1985. With its roots in a small workshop-style gathering of a group called the 'NF Consortium' dedicated to cloning the genes underlying the Neurofibromatoses, the NF Conference has grown to a gathering of three hundred NF researchers and clinicians from around the world. This meeting is recognized as the premier annual gathering of international NF researchers and physicians. Major contributors to this growth are the significant advances made in NF research in recent years and, particularly, recent advances into clinical trials and drug therapy development. In addition, state-of-the-art genomic approaches have identified mutations in the NF genes as contributors to numerous types of sporadic cancers, signaling pathways including the Hippo and Ras cascades are implicated in NF, and it is now recognized that mutations in genes along the Ras pathway result in a set of disorders, including NF1, called the "Rasopathies". Traditionally a forum for research information exchange and consensus building, in recent years the NF Conference is also the principal international forum for reporting on the neurofibromatosis preclinical therapeutic pipeline and the expanding arena of neurofibromatosis clinical trials.

描述（由申请人提供）：自1985年以来，儿童肿瘤基金会（CTF）每年组织一次神经纤维瘤病（NF）会议。NF会议起源于一个名为“NF联盟”的小组的小型研讨会式聚会，该小组致力于克隆神经纤维瘤病的潜在基因，NF会议已发展成为来自世界各地的300名NF研究人员和临床医生的聚会。这次会议被公认为是国际NF研究人员和医生的首要年度聚会。这一增长的主要贡献者是近年来在NF研究方面取得的重大进展，特别是最近在临床试验和药物治疗开发方面取得的进展。此外，最先进的基因组方法已经确定NF基因的突变是许多类型散发性癌症的诱因，包括河马和Ras级联在内的信号通路与NF有关，现在人们认识到Ras通路上的基因突变导致一系列疾病，包括NF1，称为“Rasopathies”。传统上是研究信息交流和建立共识的论坛，近年来，NF会议也成为报告神经纤维瘤病临床前治疗管道和扩大神经纤维瘤病临床试验领域的主要国际论坛。