Molecular Physiology Core Applied to Acute Lung Injury

描述(由申请人提供)：此P30申请寻求提供资源，以招聘埃里克·施密特博士领导分子生理学和影像核心(MPIC)在肺科学和重症监护医学部。该部门总部设在丹佛大学，包括该大学的附属教员(在国家犹太人健康、丹佛健康和医院系统以及丹佛退伍军人医院)。研究专长包括急性肺损伤(ALI)、肺高压、肺癌、慢性阻塞性肺疾病、职业医学、间质性肺疾病和哮喘等。该分部是美国国立卫生研究院资助的CO临床和转化科学、CO大学综合癌症中心和心血管肺研究(CVP)实验室项目资助项目的完整参与者。该司拥有每个NHLBI肺科临床网络的成员资格，包括ARDSNet、COPDnet、IPFnet和哮喘临床研究网络(ACRN)。该司已经收集了大量的机构资源，以实施转化性肺病研究方案，这将支持MPIC。MPIC将以阿里为重点，以其多变的表现形式。这种强调是基于ALI的总体相关性和致病机制的广度，这些机制最终是几种肺部疾病过程的一部分。MPIC的专业知识还将扩展到肺动脉高压、间质性肺疾病和香烟烟雾引起的肺损伤的研究。选择聘请施密特博士来建立这一核心是基于招聘、专业发展、职业支持和长期保留计划的选择性过程。在PI、Mark Geraci博士、Ivor Douglas博士和Rubin Tuder博士的直接支持下，Schmidt博士将协调附属项目、医学院内的科和部门(医学、麻醉学和儿科)、科罗拉多州CTSI以及涉及中心副总裁和医学系成像核心的计划倡议之间的互动。一个研究委员会将协助施密特博士管理Core，该委员会将包括几名由NIH资助的肺部疾病研究人员。一项评估核心、科学生产力和施密特博士的职业发展和指导的计划已经到位。 这项建议的目标是急性肺损伤的综合生理和成像研究，每年涉及19万名患者。拟议的MPIC为成功地从临床数据和相关模型系统转化为临床数据和相关模型系统提供了一个中心实验要素，因为它与一系列其他方法协同作用，这些方法单独地不能解决包括急性肺损伤在内的肺部疾病的复杂性。

DESCRIPTION (provided by applicant): This P30 application seeks to provide resources to recruit Dr. Eric Schmidt to lead the Molecular Physiology and Imaging Core (MPIC) in the Division of Pulmonary Sciences and Critical Care Medicine. The Division is based at the University of CO Denver and encompasses the University's affiliate faculty (at National Jewish Health, Denver Health and Hospital System, and the Denver VA Hospital). The research expertise encompasses acute lung injury (ALI), pulmonary hypertension, lung cancer, COPD, occupational medicine, interstitial lung diseases and asthma, among others. The Division is an integral participant of the NIH-funded CO Clinical and Translational Sciences, University of CO Comprehensive Cancer Center, and Program Project Grant in the Cardiovascular Pulmonary Research (CVP) Lab. The Division has membership in every NHLBI Lung Division Clinical Network, including the ARDSnet, COPDnet, IPFnet, and the Asthma Clinical Research Network (ACRN). The Division has gathered substantial institutional resources to implement the Program in Translational Lung Research, which will support the MPIC. The MPIC will be built with a focus on ALI, in its protean manifestations. This emphasis is based on the overall relevance of ALI and the breadth of pathogenetic mechanisms, which ultimately are part of several lung disease processes. The expertise of the MPIC will also extend to studies in pulmonary hypertension, interstitial lung disease, and cigarette smoke induced lung injury. The choice to recruit Dr. Schmidt to establish this Core was based on a selective process of recruitment, professional development, career support, and long-term retention plans. With the direct support of the PI, Dr. Mark Geraci, and Drs. Ivor Douglas and Rubin Tuder, Dr. Schmidt will coordinate the interaction across affiliated programs & the Division & Departments within the medical school (Medicine, Anesthesiology and Pediatrics), the Colorado CTSI, and programmatic initiatives involving the CVP, and the imaging core at the Department of Medicine. A research committee, which will include several established NIH-funded investigators in lung diseases, will assist Dr. Schmidt with the administration of the Core. A plan to assess the Core, scientific productivity, and Dr. Schmidt's career development & mentorship are in place. This proposal targets the integrated physiological and imaging study of acute lung injury, which compromises 190,000 patients per year. The proposed MPIC provides a central experimental element for the successful translation from/to clinical data and relevant model systems, as it synergizes with a range of other methodologies, which in isolation cannot address the complexity of pulmonary diseases, including acute lung injury.