CANCER GENETICS AND EPIGENETICS

癌症遗传学和表观遗传学

• 批准号: 7944873
• 负责人: Paul William Doetsch
• 金额: $ 7.98万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-07 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944873
• 关键词: Accounting; Address; Allelic Imbalance; Antineoplastic Agents; Architecture; Area; Basic Science; Behavioral; Biochemical; Biological Markers; Biological Models; Cancer Center Support Grant; Chromatin; Chromosomal Instability; Chromosome abnormality; Collaborations; Computer Simulation; DNA; DNA Damage; DNA Modification Process; DNA Repair; Development; Epigenetic Process; Event; Funding; Gene Expression; Gene Mutation; Genetic; Genome; Genomic Instability; Human; Institutes; Investigation; Maintenance; Malignant Neoplasms; Molecular; Mutagenesis; Nuclear; Nucleic Acids; Publications; Publishing; Suppressor Genes; Tumor Suppressor Genes; antitumor agent; cancer cell; cancer diagnosis; cancer genetics; chromatin modification; chromatin remodeling; college; drug development; functional genomics; genetic variant; medical schools; member; novel; outcome forecast; programs; response; tumor; tumorigenesis

Program 1. Cancer Genetics and Epigenetics (CGE): DNA damage, genetic mutations, genomic instability and alterations in DNA/chromatin modifications that modify gene expression are all critical events that contribute to the development of cancers in humans. The primary themes of the CGE Program reflect a major emphasis on basic science investigations directly related to oncogenesis. The CGE Program's four main thematic areas are: (1) DNA damage, repair, mutagenesis and genetic instability; (2) epigenetics, including DNA and chromatin modification and chromatin remodeling; (3) chromosome instability and nuclear architecture; (4) cancer genetics and functional genomics. The aims of the CGE Program are: (1) To elucidate the underlying molecular and biochemical mechanisms that result in the establishment and maintenance of genetic instability during tumor development and progression. (2) To elucidate and understand how epigenetic modifications of DNA and chromatin structural components impact gene expression programs and other nucleic acid transactions during tumorigenesis. (3) To understand the mechanisms underlying chromosomal aberrations, allelic imbalances and alterations in nuclear architecture and their contributions to multi-step tumorigenesis. (4) To identify and characterize novel oncogenes and tumor suppressor genes and to develop genome-scale discovery and analysis platforms and computational models to identify genetic loci and genetic variants involved in tumorigenesis. The CGE Program is comprised of 26 members from 10 departments within the School of Medicine and Emory College. Currently, there are 24 funded program members with total support of approximately $9 million per year, of which NCI funding represents $3.9M ($2.6M direct). From 2003-2008 the CGE program members published 400 articles. Of these total publications, 39 (9.75%) are intraprogrammatic collaborations and 82 (20.5%) are interprogrammatic collaborations. From 2006-2008, CGE members published 183 articles. Intraprogrammatic collaborations account for 21 (11.5 %) and interprogrammatic collaborations account for 39 (21.3 %) of these publications.

程序1.癌症遗传学和表观遗传学（CGE）：DNA损伤，基因突变，基因组 改变基因表达的DNA/染色质修饰的不稳定性和改变都是关键事件 导致人类癌症的发生。专家咨询小组方案的主要专题反映了 主要强调与肿瘤发生直接相关的基础科学研究。CGE计划的四个 主要专题领域是：（1）DNA损伤、修复、诱变和遗传不稳定性;（2）表观遗传学， 包括DNA和染色质修饰和染色质重塑;（3）染色体不稳定性和核 （4）癌症遗传学和功能基因组学。CGE计划的目标是：（1） 阐明导致建立的潜在分子和生化机制， 在肿瘤发展和进展期间维持遗传不稳定性。(2)为了澄清和 了解DNA和染色质结构成分的表观遗传修饰如何影响基因 表达程序和肿瘤发生过程中的其他核酸交易。(3)了解 染色体畸变、等位基因失衡和核结构改变的潜在机制 以及它们对多步骤肿瘤发生的贡献。(4)鉴定和表征新的癌基因， 肿瘤抑制基因，并开发基因组规模的发现和分析平台， 用于识别肿瘤发生中涉及的遗传基因座和遗传变异的模型。CGE计划是 由来自医学院和埃默里学院10个系的26名成员组成。 目前，有24个受资助的计划成员，每年的资助总额约为900万美元， 其中NCI资金为390万美元（直接260万美元）。2003-2008年，专家咨询小组方案成员发表了 400篇文章。在这些出版物中，39篇（9.75%）是方案内合作，82篇（20.5%）是 方案间合作。2006-2008年，专家咨询小组成员发表了183篇文章。 方案内合作占21个（11.5%），方案间合作占21个（11.5%）。 39篇（21.3%）。