Administrative Core

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Introduction It was noted in Critiques 1 and 2 that the regularity and function of meetings with the External (EAB) and Internal (IAB) Advisory Boards be clearly indicated and described. It was also recommended that one annual, on-site meeting involving the EAB, IAB and PPG project leaders be held for the purpose of evaluating the progress of individual projects. As indicated below (text and Table 2), we plan to hold one annual Program Project retreat in addition to the other regularly scheduled, recurring PPG-related meetings. We apologize for not making this clear in the original submission. Core A is the Administrative Core and will be utilized by all projects and the Scientific Core. The Administrative Core will facilitate the research conducted by the projects and will serve as the administration center for the Program. This core will require the effort of an administrator (33% effort) to handle and coordinate all of the activities related to the administration of the Program. The current Research Program Coordinator is Ms. Stacy Holloway, C.R.A., who will continue to function in this role. The Administrative Core will be under the direction of Dr. Paul W. Doetsch, the Program Director. Dr. David Lambeth, the Deputy Program Director will function as vice director of the Administrative Core and assist Dr. Doetsch in various administrative capacities. During the previous support period of the Program Project ("Cellular Responses to Genotoxic Stress"), two of the five original projects left Emory University. The former Project 3 Principal Investigator, Wolfram Siede, relocated to the University of Texas Heath Sciences Center in Ft. Worth Texas at the end of the first year of the grant; Gerald Shadel, Project 1 Principal Investigator relocated to Yale University in New Haven Connecticut during year 2 of the Program Project Grant. It was the responsibility of the Program Administrator to assist with the establishment of the subcontracts and insure that communication between the investigators was not affected by the moves. Ms. Holloway facilitated the timely submission of all yearly progress reports, visits from the External Advisory board members to Emory University, Yale University and the University of Texas Heath Sciences Center in Ft. Worth Texas as well as coordination of bi-monthly shipments of prepared media to both subcontracts from the Equipment Core. Additionally, it is the responsibility of Ms. Holloway to organize and coordinate the Competitive Renewal Application. The activities of the Administrative Core will continue to include coordination of the monthly meetings of the Program faculty and the monthly Program research presentations by the research groups comprising Projects 1 through 4 plus the Mouse Tumor Models Core. Activities include, but are not limited to coordination of faculty and laboratory research group schedules, planning and executing meetings and generation of meeting minutes and summaries, travel and reservation planning and budget administration. Other activities will include the scheduling and execution of quarterly meetings with the Internal Advisory Board and the Program Project Faculty. Scheduling visits and communication with the External Advisory Board will also be the responsibility of Core A. The purposes of such meetings will be to review Program Project accomplishments, discuss significant changes in focus and direction of individual projects and to provide general advice and feedback related to project interrelationships. In addition, as was done during the previous support period, at the monthly Program Project Leaders' meeting, discussion of Program resource issues (budget, utilization of Program administrator effort, and other appropriate issues) will take place. The Administrative Core prepares and maintains the overall records for the Program Project and prepares reports related to Program activities, including Progress Reports and meeting summaries. Other functions include Program correspondence, Progress Reports, manuscripts and other publications. Ms. Holloway also directly assists in the preparation of manuscripts generated from Project 2 and assists in other administrative manners. The Administrative Core is located in 4027 Rollins Research Center, nearby to the offices of Drs. Doetsch, Lambeth and Grouse and is fully equipped for secretarial and other administrative activities. The project use of the Administrative Core by the various components of the Program are shown in Table 1-CORE A, below.