INTERFERON STIMULATED GENES WITH ANTIVIRAL PROPERTIES TO HIV-1

干扰素刺激基因具有抗 HIV-1 病毒特性

• 批准号: 7950962
• 负责人: CHRISTOPHER H WOELK
• 金额: $ 0.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950962
• 关键词: Antiviral Agents; Blood; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Genes; Grant; HIV; HIV-1; Human; Institution; Interferon Type I; Interferons; Life Cycle Stages; Property; Research; Research Personnel; Resources; Source; Staging; United States National Institutes of Health; Variant; macrophage; monocyte; protective effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the variation in the anti-HIV properties of different species of Type I interferon (IFN), identify interferion-stimulated gens (ISGs) with anti-HIV properties and determine the stage of the HIV life cycle upon which they exert their inhibitory effect. These aims will be realized by analyzing the protective effect of IFN on monocyte-derived macrophages (MDMs) that must be isolated from the blood of human donors.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 确定不同种类的I型干扰素（IFN）的抗HIV特性的变化，鉴定具有抗HIV特性的干扰素刺激基因（ISG），并确定它们发挥抑制作用的HIV生命周期阶段。这些目标将通过分析IFN对单核细胞衍生的巨噬细胞（MDM）的保护作用来实现，所述MDM必须从人类供体的血液中分离。