INTERFERON STIMULATED GENES WITH ANTIVIRAL PROPERTIES TO HIV-1

干扰素刺激基因具有抗 HIV-1 病毒特性

• 批准号: 8166821
• 负责人: CHRISTOPHER H WOELK
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166821
• 关键词: Antiviral Agents; Blood; Computer Retrieval of Information on Scientific Projects Database; Funding; Genes; Grant; HIV; Human; Institution; Interferon Type I; Interferons; Life Cycle Stages; Property; Research; Research Personnel; Resources; Source; Staging; United States National Institutes of Health; Variant; macrophage; monocyte; protective effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the variation in the anti-HIV properties of different species of Type I interferon (IFN), identify interferion-stimulated gens (ISGs) with anti-HIV properties and determine the stage of the HIV life cycle upon which they exert their inhibitory effect. These aims will be realized by analyzing the protective effect of IFN on monocyte-derived macrophages (MDMs) that must be isolated from the blood of human donors.

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