Q10 AND GULF WAR VETERANS

Q10 和海湾战争退伍军人

• 批准号: 7950995
• 负责人: BEATRICE A GOLOMB
• 金额: $ 1.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950995
• 关键词: Accounting; Assimilations; Clinical Research; Coenzyme Q10; Computer Retrieval of Information on Scientific Projects Database; Cross-Over Studies; Dose; Double-Blind Method; Dropout; Fatigue; Funding; Grant; Gulf War; Headache; Individual; Institution; Measures; Modification; Pain; Participant; Placebos; Protocols documentation; Quality of life; Randomized; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Serum; Shortness of Breath; Sleep Disorders; Source; Surveys; Symptoms; Time; United States National Institutes of Health; Veterans; gastrointestinal; improved; muscle strength; oxidation; response; treatment duration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using a double blind, randomized crossover trial of coEnzyme Q10 (Q10) 100mg three times a day (tid), 200mg tid, or placebo for (four) 3 month treatment periods in 40 (8 extra participants will be recruited to account for dropouts, 32 subjects are expected to complete the protocol) subjects, we propose to assess the hypotheses that: 1. Q10 will improve overall subjective quality of life (QOL) in ill Gulf War Veterans (GWV), using a single item QOL measure. 2. Q10 will improve specific symptoms that dominate definitions of illness in GWV including fatigue, pain, and muscle strength. 3. Q10 will subjectively improve other symptoms reported to arise at elevated rates in GWV defined by responses on a symptom survey (e.g. headache, shortness of breath, sleep problems, gastrointestinal problems). 4. Effect modification: The magnitude of Q10 benefit may be influenced by baseline oxidative state, change in oxidation with Q10, and serum Q10 level; or by which symptoms a veteran has. 5. Dose response. We seek to assess whether higher dose Q10 provides greater (or the same, lesser) benefit; or does so selectively in individuals with more unfavorable baseline oxidation state; or individuals who require a higher dose to achieve the same change in Q10, e.g. due to impaired assimilation

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用辅酶Q10（Q10）（Q10）100mg每天3次（TID），200mg TID或安慰剂的双盲，随机分跨试验（四个）40的3个月治疗期（将招募8个额外的参与者，以说明32名受试者，预计有32名受试者将完成协议的受试者，我们建议评估以下方面的假设： 1。Q10将使用单个项目QOL量度来改善Ill Gulf战争退伍军人（GWV）的总体主观生活质量（QOL）。 2。Q10将改善特定症状，这些症状主导了GW​​V中疾病定义的定义，包括疲劳，疼痛和肌肉力量。 3. Q10将主观改善其他症状以症状调查的反应（例如头痛，呼吸急促，睡眠问题，胃肠道问题）定义为GWV的其他症状。 4。效应修饰：Q10益处的幅度可能受基线氧化态，Q10氧化和血清Q10水平的影响；或老兵的症状。 5。剂量反应。我们试图评估较高剂量的Q10是否提供更大（相同的，较小）的好处；或在具有更不利的基线氧化态的个体中选择性地做到了；或需要更高剂量才能实现相同变化的个人，例如由于同化受损