Coenzyme Q10 in Aging: A Planning Grant

辅酶 Q10 在衰老中的作用：规划补助金

• 批准号: 6957790
• 负责人: BEATRICE A GOLOMB
• 金额: $ 13.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6957790
• 关键词: aging; chemoprevention; clinical research; clinical trials; dietary supplements; drug screening /evaluation; functional ability; human middle age (35-64); human old age (65+); human subject; mitochondria; pharmacokinetics; quality of life; questionnaires; therapy design /development; ubiquinone

DESCRIPTION (provided by applicant): We propose to conduct a planning grant (R34) in which we will develop specific procedures, protocols, and assessments fora clinical trial evaluating the impact of coenzyme Q10 (Q10) on aging. The aims of the planning grant include generation of protocols and flow sheets for recruitment, laboratory management, quality control, data management and data sharing; finalization of the protocol and report forms; pilot testing for feasibility and acceptability of trial elements, then of the full protocol on age-relevant subjects; and development of the Manual of Operations. We propose to use these products to conduct a randomized, double blind, placebo-controlled trial to assess the impact of Q10 on outcomes germane to aging, including quality of life (QOL) (primary). We will leverage the substantial costs of conducting a RCT by secondarily addressing specific elements that are affected in aging and contribute to QOL, and for which there is preliminary support for benefit by Q10. These include muscle function, energy, cognitive function, pain, activity and sleep. We will further assess how measures of mitochondrial (mt) function relate to aging outcomes; and how Q10 affects these measures. Changes in mt function are increasingly viewed as a critical part of the aging process. Furthermore, Q10 is increasingly used as a supplement to protect against elements of aging. Q10 is a pivotall mitochondiral nutrient that serves key respiratory chain, redox, antioxidant, and antiapoptic function. It increases levels of other antioxidant nutrients; bypasses respiratory chain enzyme defects; and increases mt number. It has been reported to provide clinical benefits of relevance to aging and QOL including improvement in energy, exercise tolerance, blood pressure and glucose tolerance; and protection against arrhythmia, heart failure, and neurodegenerative disease. Thus there is strong conceptual as well as clinical rationale for assessing whether Q10 provides QOL & functional benefits in aging and whether it protects against untoward events associated with age.

描述（由申请人提供）：我们建议进行计划赠款（R34），其中我们将开发特定的程序，方案和评估，以评估辅酶Q10（Q10）对衰老的影响。规划赠款的目的包括生成招聘，实验室管理，质量控制，数据管理和数据共享的协议和流平面；协议和报告表的最终确定；试点测试，以实现试验元素的可行性和可接受性，然后是与年龄相关的受试者的完整协议；和手册的制定。我们建议使用这些产品进行随机，双盲，安慰剂对照试验，以评估Q10对emantes emanne对衰老的影响，包括生活质量（QOL）（QOL）（主要）。我们将利用进行RCT的巨额成本，其次解决在衰老中受到影响并促成QOL的特定要素，并为Q10提供初步支持。这些包括肌肉功能，能量，认知功能，疼痛，活动和睡眠。我们将进一步评估线粒体（MT）功能的测量与衰老结果如何相关；以及Q10如何影响这些措施。 MT功能的变化越来越被视为衰老过程的关键部分。此外，Q10越来越多地用作防止衰老要素的补充。 Q10是一种枢纽线粒体营养素，可提供关键的呼吸链，氧化还原，抗氧化剂和抗抗原功能。它增加了其他抗氧化剂营养素的水平；绕过呼吸链酶缺陷；并增加了MT号。据报道，它可以为与衰老和QOL相关的临床益处，包括改善能量，运动耐受性，血压和葡萄糖耐受性；防止心律不齐，心力衰竭和神经退行性疾病。因此，有很强的概念和临床原理用于评估Q10是否提供QOL和功能 衰老的好处以及它是否可以防止与年龄相关的不良事件。