SENSITIVITY OF DIFFUSION TENSOR IMAGING (DTI) IN MILD TO MODERATEL PEDIATRIC TRA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是探讨有轻、中度闭合性脑损伤病史的儿童/青少年(10-17岁)和健康对照儿童/青少年之间的脑结构和神经认知的差异。该项目试图证明，在遭受轻到中度头部损伤的年轻人中，微结构白质完整性可能会受到损害，并且这些白质异常可能与神经认知功能受损有关。我们建议使用扩散张量成像(DTI)来研究这一人群中的白质异常，这是一种以前从未被用于研究这一患者群体的磁共振成像(MRI)方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the structural and neurocognitive brain differences between children/adolescents (ages 10-17) with a history of mild to moderate closed head injury and healty controls. This project seeks to demonstrate that microstructural white matter integrity may be compromised in youth who have suffered mild to moderate head injury and that these white matter abnormalities may be associated with impaired neurocognitive functioning. We propose to investigate white matter abnormalities in this population by using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) method that has not previously been used to explore this patient population.