NEURODEVELOPMENTAL EFFECTS OF FETAL ALCOHOL EXPOSURE

胎儿酒精暴露对神经发育的影响

• 批准号: 7951660
• 负责人: JEFFREY ROBERT WOZNIAK
• 金额: $ 1.06万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951660
• 关键词: Alcoholism; Attention; Brain; Brain Part; Child; Clinic; Clinical Data; Clinical Research; Cognitive; Communication; Computer Retrieval of Information on Scientific Projects Database; Data; Diffusion Magnetic Resonance Imaging; Evaluation; Fetal Alcohol Exposure; Fetal Alcohol Syndrome; Funding; Grant; Imaging Techniques; Impaired cognition; Institution; Language; Magnetic Resonance Imaging; Memory; Methods; Motor Skills; Neurocognitive; Patients; Research; Research Personnel; Resources; Schizophrenia; Series; Source; Testing; United States National Institutes of Health; executive function; neuropsychological; normal aging; research study; skills; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will use Magnetic Resonance Imaging (MRI) and cognitive tests to look for brain abnormalities in children with Fetal Alcohol Exposure (FAE). We will use Diffusion Tensor Imaging (DTI), a newer imaging technique which allows for the detailed study of white matter in the brain. White matter is particularly important for communication among different parts of the brain and its disruption leads to numerous cognitive impairments. Dr. Lim's group has used DTI in a series of clinical research studies and have demonstrated alterations in white matter in normal aging, schizophrenia and alcoholism. This promising method has not yet been applied to the study of brain abnormality in either FAS (Fetal Alcohol Syndrome) or FAE. We will also use data from clinical neuropsychological assessments in this study. Patients who participate in the study will be asked to allow the researchers to use the neurocognitive data collected as part of their evaluation in the Fetal Alcohol Syndrome Clinic. This data will include information about the patient's intellectual functioning, language skills, attention, executive functioning, memory, and motor skills.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们将使用磁共振成像 (MRI) 和认知测试来寻找胎儿酒精暴露 (FAE) 儿童的大脑异常。我们将使用扩散张量成像（DTI），这是一种较新的成像技术，可以对大脑中的白质进行详细研究。白质对于大脑不同部分之间的交流特别重要，其破坏会导致许多认知障碍。 Lim 博士的团队在一系列临床研究中使用了 DTI，并证明了正常衰老、精神分裂症和酗酒时白质的变化。这种有前途的方法尚未应用于 FAS（胎儿酒精综合症）或 FAE 中大脑异常的研究。我们还将在本研究中使用临床神经心理学评估的数据。参与该研究的患者将被要求允许研究人员使用收集的神经认知数据，作为胎儿酒精综合症诊所评估的一部分。这些数据将包括有关患者智力功能、语言技能、注意力、执行功能、记忆和运动技能的信息。