MEXICAN AMERICAN ADMIXTURE MAPPING DEVELOPMENT AND APPLICATION TO NIDDM (NON-

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 墨西哥裔美国人非胰岛素依赖型糖尿病(NIDDM)混合图谱的开发与应用 混合作图是一种正在发展中的检测复杂遗传病的方法，它补充了连锁分析和关联方法。对于任何疾病，如果在构成混合种群的亲本种群中存在不同的易感基因分布，则可以使用最近混合的种群来定义关键的染色体区域。这是基于确定混合种群中染色体片段的祖先的能力。 这项研究旨在提供改进的工具，使用一种称为混合图谱的分子遗传学策略来阐明糖尿病肾病和2型糖尿病的遗传基础。这是利用了这样一个事实，即已知某些群体在历史上的某个时候是不同基因祖先的混合体。在这种情况下，要研究的人群是墨西哥裔美国人群体，他们代表了美洲印第安人和欧洲人的混合遗传背景。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mexican American Admixture Mapping Development and Application to NIDDM (Non-Insulin Dependent Diabetes) Admixture mapping is a developing method for examining complex genetic diseases that complements linkage analysis and association methods. For any disease, a recently admixed population can be used to define critical chromosomal regions if there is a different distribution of susceptibility genes in parental populations contributing to the admixed population. This is predicated on the ability to define the ancestry of the chromosomal segments in the admixed population. This study is designed to provide improved tools to elucidate the genetic basis for diabetic nephropathy and Type 2 diabetes using a molecular genetics strategy known as admixture mapping. This uses the fact that certain populations are known to be a mixture of different genetic ancestry at some point in history. In this case, the population to be studied is the Mexican American group who represent an admixture of Amerindian and European genetic backgrounds.