INSULINOPENIC TYPE 2 DIABETES IN HISPANICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的具体目标是测试以下假设：在洛杉矶南湾地区有一个独特的人群患有胰岛素分泌DM-2，通过他们的表现可以识别为2型糖尿病中酮症的酮症酸中毒综合征，SKIT-2。我们的第一个目标是检验这一假设，即这些患者代表了更大的2型糖尿病患者群体中的一个独特的流行病学亚群。我们假设，与没有经历过酮症酸中毒的匹配的DM-2受试者相比，在DKA后3个月的随访中，患有SKIT-2的患者将继续表现出胰岛素减少症。这一点将通过对胰岛素分泌和敏感性的心理学研究来检验。在这些研究中，我们将把重点放在西班牙裔主题上，以便在研究对象中获得一定程度的同质性。一些受试者将在已知的糖尿病基因中发生突变。这将通过筛查Skit-2先证者的线粒体DNA和HNF-1α突变来进行评估。一旦这个项目得到资助，先证者的人类白细胞抗原分型工作也将完成。在那之前，DNA将被储存，和/或淋巴细胞将被获得并转化，以供以后研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our specific aims are to test the following hypotheses: There is a distinct population in the Los Angeles South Bay area that have insulinopenic DM-2, identifiable by their presentation with ketoacidosis Syndrome of Ketosis In Type 2 Diabetes, SKIT-2. Our first aim is to test the hypothesis that these patients represent a distinct epidemiological subgroup within the larger patient population of type 2 diabetes mellitus. We hypothesize that patients with SKIT-2 will continue to show insulinopenia at follow up over 3 months after DKA, when compared with matched DM-2 subjects who have not experienced ketoacidosis. This will be tested using psychological studies of insulin secretion and sensitivity. In these studies we will focus upon Hispanic subjects so as to obtain a degree of homogeneity in the subjects studied. Some subjects will have a mutation in a known diabetes gene. This will be assessed by screening SKIT-2 probands for mutations in mitochondrial DNA and HNF-1alpha. HLA typing of probands will also be done once this project is funded. Until then, DNA will be stored and/or lymphocytes will be obtained and transformed for later study.