ADOLESCENT MASTER PROTOCOL (AMP) - IMPACT OF HIV AND ART ON GROWTH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 确定HIV感染和ART对围产期HIV感染的青少年从青春期到成年期的生长和青春期发育(及其激素调节)以及认知、学习和社会发育的影响；识别HIV疾病的感染和非感染性并发症，并评估它们与ART的关系；调查葡萄糖代谢、身体成分和骨矿化的变化；调查脂代谢和其他心血管疾病危险因素的变化；认知和行为的变化；HIV二次传播的危险因素；女性宫颈HPV感染的发生和临床病程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To define the impact of HIV infection and ART on growth and pubertal development (and their hormonal regulation) along with the cognitive, academic, and social development, of pre-adolescents and adolescents with perinatal HIV infection as they move through adolescence into adulthood;To identify infectious and non-infectious complications of HIV disease and evaluate their associations with ART; Investigate changes in glucose metabolism, body composition and bone mineralization; Investigate changes in lipid metabolism and other risk factors for cardiovascular disease; Cognitive and behavioral changes over time; Risk factors for secondary transmission of HIV; Occurence and clinical course of cervical HPV infections among females.