METABOLIC SYNDROME FOLLOWING TRANSPLANT FOR LEUKEMIA

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们建议开展一项临床研究，以接受造血细胞移植（HCT）的儿童白血病青少年和年轻幸存者为样本，评估胰岛素抵抗、生长激素缺乏和其他胰岛素抵抗介质与代谢综合征发生之间的关系；比较 HCT 幸存者与普通人群代谢综合征的患病率；并将胰岛素抵抗和代谢综合征的具体测量值与以类似方式研究的年龄/性别匹配的对照受试者进行比较。我们还将调查患有代谢综合征的 HCT 幸存者与没有代谢综合征的患者相比，内皮损伤和心血管疾病的其他早期症状是否明显更为普遍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to conduct a clinical study to evaluate the relation between insulin resistance, growth hormone deficiency and other mediators of insulin resistance, with the development of metabolic syndrome in a sample of adolescent and young adult survivors of childhood leukemia who underwent hematopoietic cell transplant (HCT); to compare the prevelance of metabolic syndrome in HCT survivors to the general population; and to compare specific measures of insulin resistance and metabolic syndrome to age/sex matched control subjects that have been studied in a similar fashion. We will also investigate whether endothelial impairment and other early signs of cardiovascular disease are significantly more prevalent among HCT survivors with metabolic syndrome, compared to those without metabolic syndrome.