NUTRITIONAL INTERVENTION TO PREVENT (NIP) TYPE 1 DIABETES PILOT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项双臂、多中心、随机、双掩蔽、对照的临床试验。这项研究的总体目标是确定高危婴儿或高危新生儿的孕妇补充omega-3脂肪酸(二十二碳六烯酸[DHA])是否可以防止胰岛细胞自身免疫的发展，从而阻止1型糖尿病的发生。这目前是一项试验性研究。这项研究的结果将用于评估全面试验的可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two-arm, multicenter, randomized, double-masked, controlled clinical trial. The overall objective of this study is to determine whether supplementation with an omega-3 fatty acid, (docosahexaenoic acid [DHA]), in pregnant mothers of a high risk infant or in high risk newborns will prevent the development of islet cell autoimmunity that precludes the onset of type 1 diabetes mellitus. This is currently a pilot study. The results of this study will be used to assess the feasibility of a full scale trial.