LUPRON DEPOT IN THE TREATMENT OF CENTRAL PRECOCIOUS PUBERTY

LUPRON Depot 治疗中枢性性早熟

• 批准号: 7951301
• 负责人: PETER A LEE
• 金额: $ 0.09万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951301
• 关键词: Abdomen; Child; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Enantone; Female; Follow-Up Studies; Funding; Grant; Height; Institution; Leuprolide Acetate; Long-Term Effects; Measurement; Office Visits; Participant; Precocious Puberty; Questionnaires; Reproductive Health; Research; Research Personnel; Research Subjects; Resources; Source; Time; Ultrasonography; United States National Institutes of Health; Weight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have indicated that leuprolide acetate (Lupron Depot) is efficacious in the treatment of precocious puberty. In the late 1990's Dr. Lee and research subjects at HMC participated in some of these clinical trials. The purpose the proposed research study is to determine the long-term effects of using Lupron in children with central precocious puberty. Approximately 50 people will take part in this research nationwide and about 9 subjects who were previously studied at HMC are expected to take part at this follow up study. Each subject will be asked to have one or two office visits in the GCRC, at which time the following assessments will be completed: height Measurement, weight Measurement, completion of a brief questionnaire that will ask about reproductive health, and an abdominal Ultrasound for female participants.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 先前的研究表明，醋酸亮丙瑞林（Lupron Depot）可有效治疗性早熟。 1990 年代末，Lee 博士和 HMC 的研究对象参与了其中一些临床试验。 拟议研究的目的是确定使用亮丙瑞林对中枢性性早熟儿童的长期影响。 全国范围内将有大约 50 人参加这项研究，预计先前在 HMC 研究过的大约 9 名受试者将参加这项后续研究。 每个受试者将被要求到 GCRC 进行一到两次办公室访问，届时将完成以下评估：身高测量、体重测量、完成一份询问生殖健康的简短调查问卷，以及对女性参与者进行腹部超声检查。